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Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma.

Publication ,  Journal Article
Griebel, M; Friedman, HS; Halperin, EC; Wiener, MD; Marks, L; Oakes, WJ; Hoffman, JM; DeLong, GR; Schold, SC; Hockenberger, B
Published in: Med Pediatr Oncol
1991

Two patients with brain stem gliomas were treated with hyperfractionated radiation therapy (HFR) (7,020 and 7,560 cGy, respectively). Despite initial clinical improvement during irradiation, both patients demonstrated clinical deterioration approximately 3 weeks after completion of radiotherapy. Cranial magnetic resonance imaging (MRI) revealed a progressive increase in distribution of abnormal brain stem signal consistent with either tumor or edema. 18FDG positron emission tomography (PET) was obtained in one patient and demonstrated a hypermetabolic lesion at diagnosis and a hypometabolic lesion at the time of clinical deterioration postirradiation. Management with a tapering dose of dexamethasone alone resulted in marked clinical (both patients) and radiographic (one patient) improvement, allowing reduction or discontinuation of this medication. These results suggest that patients with brain stem tumors demonstrating clinical and radiographic evidence of progressive tumor shortly after completion of HFR should be initially managed conservatively with dexamethasone, since these findings may be manifestations of reversible radiation-related neurotoxicity.

Duke Scholars

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1991

Volume

19

Issue

3

Start / End Page

182 / 186

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Radiotherapy, High-Energy
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Magnetic Resonance Imaging
  • Humans
  • Glioma
  • Female
  • Dexamethasone
  • Child
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Griebel, M., Friedman, H. S., Halperin, E. C., Wiener, M. D., Marks, L., Oakes, W. J., … Hockenberger, B. (1991). Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. Med Pediatr Oncol, 19(3), 182–186. https://doi.org/10.1002/mpo.2950190307
Griebel, M., H. S. Friedman, E. C. Halperin, M. D. Wiener, L. Marks, W. J. Oakes, J. M. Hoffman, G. R. DeLong, S. C. Schold, and B. Hockenberger. “Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma.Med Pediatr Oncol 19, no. 3 (1991): 182–86. https://doi.org/10.1002/mpo.2950190307.
Griebel M, Friedman HS, Halperin EC, Wiener MD, Marks L, Oakes WJ, et al. Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. Med Pediatr Oncol. 1991;19(3):182–6.
Griebel, M., et al. “Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma.Med Pediatr Oncol, vol. 19, no. 3, 1991, pp. 182–86. Pubmed, doi:10.1002/mpo.2950190307.
Griebel M, Friedman HS, Halperin EC, Wiener MD, Marks L, Oakes WJ, Hoffman JM, DeLong GR, Schold SC, Hockenberger B. Reversible neurotoxicity following hyperfractionated radiation therapy of brain stem glioma. Med Pediatr Oncol. 1991;19(3):182–186.

Published In

Med Pediatr Oncol

DOI

ISSN

0098-1532

Publication Date

1991

Volume

19

Issue

3

Start / End Page

182 / 186

Location

United States

Related Subject Headings

  • Tomography, Emission-Computed
  • Radiotherapy, High-Energy
  • Radiotherapy Dosage
  • Oncology & Carcinogenesis
  • Magnetic Resonance Imaging
  • Humans
  • Glioma
  • Female
  • Dexamethasone
  • Child