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In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer.

Publication ,  Journal Article
Itharat, A; Houghton, PJ; Eno Amooquaye, E; Burke, PJ; Sampson, JH; Raman, A
Published in: Journal of ethnopharmacology
January 2004

The SRB assay was used to test cytotoxicity against three human cancer cell lines and one normal cell line of 11 Thai medicinal plant species used by traditional doctors in treating cancer patients. The extraction procedures used were similar to those practised by Thai traditional doctors (ethanolic and water extracts). Extracts were tested against the human large cell lung carcinoma cell line COR-L23, the human breast adenocarcinoma cell line MCF-7 and human colon adenocarcinoma cell line LS-174T and normal human keratinocytes SVK-14. The results showed that three plants; Dioscorea membranacea Pierre ex Prain & Burkill, Dioscorea birmanica Prain & Burkill (Dioscoreaceae) and Siphonodon celastrineus Griff. (Celastraceae), exhibited high cytotoxic activity showing a certain degree of selectivity against the different cell types.

Duke Scholars

John Howard Sampson
Author John Howard Sampson Neurosurgery

Published In

Journal of ethnopharmacology

ISSN

0378-8741

Publication Date

January 2004

Volume

90

Issue

1

Start / End Page

33 / 38

Location

ireland

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1104 Complementary and Alternative Medicine
  • 0607 Plant Biology
 

Citation

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Itharat, A., Houghton, P. J., Eno Amooquaye, E., Burke, P. J., Sampson, J. H., & Raman, A. (2004). In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. Journal of Ethnopharmacology, 90(1), 33–38.
Itharat, A., P. J. Houghton, E. Eno Amooquaye, P. J. Burke, J. H. Sampson, and A. Raman. “In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer.” Journal of Ethnopharmacology 90, no. 1 (January 2004): 33–38.
Itharat A, Houghton PJ, Eno Amooquaye E, Burke PJ, Sampson JH, Raman A. In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. Journal of ethnopharmacology. 2004 Jan;90(1):33–8.
Itharat, A., et al. “In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer.” Journal of Ethnopharmacology, vol. 90, no. 1, Jan. 2004, pp. 33–38.
Itharat A, Houghton PJ, Eno Amooquaye E, Burke PJ, Sampson JH, Raman A. In vitro cytotoxic activity of Thai medicinal plants used traditionally to treat cancer. Journal of ethnopharmacology. 2004 Jan;90(1):33–38.
Journal cover image

Published In

Journal of ethnopharmacology

ISSN

0378-8741

Publication Date

January 2004

Volume

90

Issue

1

Start / End Page

33 / 38

Location

ireland

Related Subject Headings

  • Medicinal & Biomolecular Chemistry
  • 1115 Pharmacology and Pharmaceutical Sciences
  • 1104 Complementary and Alternative Medicine
  • 0607 Plant Biology