Reversing nerve-graft polarity in a rat model: the effect on function.
To evaluate the effect of nerve-graft polarity on function, a 1-cm segment of sciatic nerve was excised and reoriented in three groups of 20 adult Sprague-Dawley rats. In one group, the nerve was cut and anastomosed in the original orientation to act as a control. In the second group, the nerve-graft polarity was reversed 180 degrees. The final group underwent reversal of polarity 180 degrees and was rotated 180 degrees, (i.e., the posterior tibial nerve fascicles proximally were opposite to the peroneal nerve fascicles distally). Functional recovery was evaluated using Bain's modification of de Medinaceli's sciatic functional index (SFI). Rat-track analysis was performed over a 120-day period. Histologic correlation was also performed at the time of sacrifice. From our study, we concluded that reversing nerve-graft polarity, with or without rotation, does not influence subsequent function in this model.
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Related Subject Headings
- Surgery
- Sciatic Nerve
- Rats
- Neural Conduction
- Nerve Transfer
- Nerve Regeneration
- Animals
- Anastomosis, Surgical
- 3203 Dentistry
- 3202 Clinical sciences
Citation
Published In
DOI
ISSN
Publication Date
Volume
Issue
Start / End Page
Location
Related Subject Headings
- Surgery
- Sciatic Nerve
- Rats
- Neural Conduction
- Nerve Transfer
- Nerve Regeneration
- Animals
- Anastomosis, Surgical
- 3203 Dentistry
- 3202 Clinical sciences