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The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model.

Publication ,  Journal Article
Chen, LE; Seaber, AV; Bossen, E; Urbaniak, JR
Published in: J Orthop Res
March 1991

Although tissue is denervated during replantation of a severed part, tissue transfer, or muscle transplantation, there are few studies concerning the effects of acute denervation on muscle microcirculation. We have described a surgical procedure that totally denervates the rat cremaster muscle. Histological examination of the denervated tissue has given convincing evidence of nerve degeneration and skeletal muscle atrophy, accompanied by electrophysiological evidence of total denervation. The diameters of each component of the microcirculation were measured before and after denervation. Arterioles and arteries ranging in size from 10 to 70 microns in diameter were found to increase significantly in size immediately after acute denervation. Larger arteries and veins did not undergo significant diametrical increases. These findings suggest that total acute denervation significantly increases the diameter of small arteries and arterioles, thereby decreasing the resistance in the arterial bed and increasing blood flow. Since this phenomenon is of limited duration (20 min), it would appear to be ineffective in enhancing reperfusion and oxygenation at the time of reattachment of amputated parts or during vascularized tissue transfers, until methods of prolonging it for several hours or more are found.

Duke Scholars

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

March 1991

Volume

9

Issue

2

Start / End Page

266 / 274

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Orthopedics
  • Muscles
  • Muscle Denervation
  • Microcirculation
  • Male
  • Blood Vessels
  • Animals
  • 4207 Sports science and exercise
 

Citation

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Chen, L. E., Seaber, A. V., Bossen, E., & Urbaniak, J. R. (1991). The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model. J Orthop Res, 9(2), 266–274. https://doi.org/10.1002/jor.1100090215
Chen, L. E., A. V. Seaber, E. Bossen, and J. R. Urbaniak. “The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model.J Orthop Res 9, no. 2 (March 1991): 266–74. https://doi.org/10.1002/jor.1100090215.
Chen LE, Seaber AV, Bossen E, Urbaniak JR. The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model. J Orthop Res. 1991 Mar;9(2):266–74.
Chen, L. E., et al. “The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model.J Orthop Res, vol. 9, no. 2, Mar. 1991, pp. 266–74. Pubmed, doi:10.1002/jor.1100090215.
Chen LE, Seaber AV, Bossen E, Urbaniak JR. The effect of acute denervation on the microcirculation of skeletal muscle: rat cremaster model. J Orthop Res. 1991 Mar;9(2):266–274.
Journal cover image

Published In

J Orthop Res

DOI

ISSN

0736-0266

Publication Date

March 1991

Volume

9

Issue

2

Start / End Page

266 / 274

Location

United States

Related Subject Headings

  • Rats, Inbred Strains
  • Rats
  • Orthopedics
  • Muscles
  • Muscle Denervation
  • Microcirculation
  • Male
  • Blood Vessels
  • Animals
  • 4207 Sports science and exercise