Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation.
Publication
, Journal Article
Milano, CA; Patel, VS; Smith, PK; Smith, MS
Published in: J Heart Lung Transplant
October 2002
Aprotinin has been shown to reduce transfusion requirements in re-operative cardiac surgery and in implantation of long-term left ventricular assist devices (LVAD). However, it is an antigenic polypeptide and re-exposure is associated with a small incidence of anaphylaxis. This report describes 2 cases of anaphylactic response to aprotinin when the agent was employed for both the LVAD implant and for the subsequent explant and cardiac transplant. Early re-exposure to just the test dose was associated with a significant incidence of anaphylaxis.
Duke Scholars
Published In
J Heart Lung Transplant
DOI
ISSN
1053-2498
Publication Date
October 2002
Volume
21
Issue
10
Start / End Page
1127 / 1130
Location
United States
Related Subject Headings
- Surgery
- Serine Proteinase Inhibitors
- Myocardial Ischemia
- Middle Aged
- Male
- Humans
- Heart-Assist Devices
- Heart Transplantation
- Female
- Device Removal
Citation
APA
Chicago
ICMJE
MLA
NLM
Milano, C. A., Patel, V. S., Smith, P. K., & Smith, M. S. (2002). Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation. J Heart Lung Transplant, 21(10), 1127–1130. https://doi.org/10.1016/s1053-2498(02)00395-9
Milano, Carmelo A., Vijay S. Patel, Peter K. Smith, and Mark Stafford Smith. “Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation.” J Heart Lung Transplant 21, no. 10 (October 2002): 1127–30. https://doi.org/10.1016/s1053-2498(02)00395-9.
Milano CA, Patel VS, Smith PK, Smith MS. Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation. J Heart Lung Transplant. 2002 Oct;21(10):1127–30.
Milano, Carmelo A., et al. “Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation.” J Heart Lung Transplant, vol. 21, no. 10, Oct. 2002, pp. 1127–30. Pubmed, doi:10.1016/s1053-2498(02)00395-9.
Milano CA, Patel VS, Smith PK, Smith MS. Risk of anaphylaxis from aprotinin re-exposure during LVAD removal and heart transplantation. J Heart Lung Transplant. 2002 Oct;21(10):1127–1130.
Published In
J Heart Lung Transplant
DOI
ISSN
1053-2498
Publication Date
October 2002
Volume
21
Issue
10
Start / End Page
1127 / 1130
Location
United States
Related Subject Headings
- Surgery
- Serine Proteinase Inhibitors
- Myocardial Ischemia
- Middle Aged
- Male
- Humans
- Heart-Assist Devices
- Heart Transplantation
- Female
- Device Removal