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The effect of chemical ablation of the endocardium on ventricular fibrillation threshold.

Publication ,  Journal Article
Damiano, RJ; Smith, PK; Tripp, HF; Asano, T; Small, KW; Lowe, JE; Ideker, RE; Cox, JL
Published in: Circulation
September 1986

The purpose of this study was to examine the effects of ablation of the superficial endocardium and Purkinje network on left ventricular fibrillation threshold. Lugol's solution was applied through small ventriculotomies to the left and right ventricular endocardium of 10 dogs on cardiopulmonary bypass. Two control groups of five animals each underwent either endocardial application of saline or epicardial application of Lugol's solution. Ventricular fibrillation threshold was measured before and after each intervention by the single-stimulus technique. Application of Lugol's solution to the endocardium resulted in a 102 +/- 15% increase in ventricular fibrillation threshold from a control value of 26 +/- 2 to 53 +/- 6 mA (p less than .005). In two animals, ventricular fibrillation could not be initiated postoperatively. In the control groups, there were no significant changes in ventricular fibrillation threshold. Histologic examination revealed that Lugol's solution obliterated less than 0.5 mm of superficial endocardium while sparing the adjacent myocardium. Electrophysiologic and rheologic data confirmed the discrete nature of the chemical injury. Thus ablation of the superficial ventricular endocardium with Lugol's solution results in a profound increase in the ventricular fibrillation threshold with only minimal tissue destruction.

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Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

September 1986

Volume

74

Issue

3

Start / End Page

645 / 652

Location

United States

Related Subject Headings

  • Ventricular Fibrillation
  • Purkinje Fibers
  • Neural Conduction
  • Iodine
  • Heart Conduction System
  • Endocardium
  • Dogs
  • Coronary Circulation
  • Cardiovascular System & Hematology
  • Atrioventricular Node
 

Citation

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Damiano, R. J., Smith, P. K., Tripp, H. F., Asano, T., Small, K. W., Lowe, J. E., … Cox, J. L. (1986). The effect of chemical ablation of the endocardium on ventricular fibrillation threshold. Circulation, 74(3), 645–652. https://doi.org/10.1161/01.cir.74.3.645
Damiano, R. J., P. K. Smith, H. F. Tripp, T. Asano, K. W. Small, J. E. Lowe, R. E. Ideker, and J. L. Cox. “The effect of chemical ablation of the endocardium on ventricular fibrillation threshold.Circulation 74, no. 3 (September 1986): 645–52. https://doi.org/10.1161/01.cir.74.3.645.
Damiano RJ, Smith PK, Tripp HF, Asano T, Small KW, Lowe JE, et al. The effect of chemical ablation of the endocardium on ventricular fibrillation threshold. Circulation. 1986 Sep;74(3):645–52.
Damiano, R. J., et al. “The effect of chemical ablation of the endocardium on ventricular fibrillation threshold.Circulation, vol. 74, no. 3, Sept. 1986, pp. 645–52. Pubmed, doi:10.1161/01.cir.74.3.645.
Damiano RJ, Smith PK, Tripp HF, Asano T, Small KW, Lowe JE, Ideker RE, Cox JL. The effect of chemical ablation of the endocardium on ventricular fibrillation threshold. Circulation. 1986 Sep;74(3):645–652.

Published In

Circulation

DOI

ISSN

0009-7322

Publication Date

September 1986

Volume

74

Issue

3

Start / End Page

645 / 652

Location

United States

Related Subject Headings

  • Ventricular Fibrillation
  • Purkinje Fibers
  • Neural Conduction
  • Iodine
  • Heart Conduction System
  • Endocardium
  • Dogs
  • Coronary Circulation
  • Cardiovascular System & Hematology
  • Atrioventricular Node