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DNA and RNA modified dendritic cell vaccines.

Publication ,  Journal Article
Morse, MA; Lyerly, HK
Published in: World J Surg
July 2002

The purpose of this paper is to describe the strategies for genetic modification of dendritic cells for use in active immunotherapy for the treatment of malignancies. An accruing body of data supports the concept of directing a therapeutic immune response, mediated by the cellular arm of the immune system, against cancers in vivo. Dendritic cells are the most potent inducers of T cell-mediated immune responses against tumor-expressed antigens, by virtue of their ability to present tumor antigens in the context of major histocompatibility molecules to naïve T cells with receptors specific for the antigen. A variety of methods for directing antigens to the MHC molecules of dendritic cells and augmenting their T cell stimulatory activity have been developed. This paper describes one group of promising strategies, the genetic modification of dendritic cells to direct the expression of tumor antigens, costimulatory molecules, and stimulatory cytokines. Genetic modification can be effected by either DNA or RNA, and the genetic material may be delivered by vectors or by physical means. These approaches are now entering human clinical trials.

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Published In

World J Surg

DOI

ISSN

0364-2313

Publication Date

July 2002

Volume

26

Issue

7

Start / End Page

819 / 825

Location

United States

Related Subject Headings

  • Surgery
  • Neoplasms
  • Immunotherapy, Active
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • Gene Transfer Techniques
  • Dendritic Cells
  • Cancer Vaccines
  • Animals
 

Citation

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Morse, M. A., & Lyerly, H. K. (2002). DNA and RNA modified dendritic cell vaccines. World J Surg, 26(7), 819–825. https://doi.org/10.1007/s00268-002-4058-0
Morse, Michael A., and H Kim Lyerly. “DNA and RNA modified dendritic cell vaccines.World J Surg 26, no. 7 (July 2002): 819–25. https://doi.org/10.1007/s00268-002-4058-0.
Morse MA, Lyerly HK. DNA and RNA modified dendritic cell vaccines. World J Surg. 2002 Jul;26(7):819–25.
Morse, Michael A., and H. Kim Lyerly. “DNA and RNA modified dendritic cell vaccines.World J Surg, vol. 26, no. 7, July 2002, pp. 819–25. Pubmed, doi:10.1007/s00268-002-4058-0.
Morse MA, Lyerly HK. DNA and RNA modified dendritic cell vaccines. World J Surg. 2002 Jul;26(7):819–825.
Journal cover image

Published In

World J Surg

DOI

ISSN

0364-2313

Publication Date

July 2002

Volume

26

Issue

7

Start / End Page

819 / 825

Location

United States

Related Subject Headings

  • Surgery
  • Neoplasms
  • Immunotherapy, Active
  • Humans
  • Genetic Vectors
  • Genetic Therapy
  • Gene Transfer Techniques
  • Dendritic Cells
  • Cancer Vaccines
  • Animals