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Attenuation of acid induced oesophagitis in VR-1 deficient mice.

Publication ,  Journal Article
Fujino, K; de la Fuente, SG; Takami, Y; Takahashi, T; Mantyh, CR
Published in: Gut
January 2006

BACKGROUND AND AIMS: Activation of the vanilloid receptor subtype 1 (VR-1) results in release of proinflammatory peptides which initiate an inflammatory cascade known as neurogenic inflammation. We investigated its role in an acute model of surgically induced oesophagitis. METHODS: Oesophagitis was induced by pyloric ligation in wild-type and VR-1 deficient mice. A subset of animals were administered the VR-1 antagonist capsazepine, famotidine, or omeprazole one hour before surgery. Five hours after surgery, myeloperoxidase activity (MPO), histological damage scores, intragastric pH, and immunocytochemical analysis of substance P (SP) receptor endocytosis were determined. RESULTS: Oesophagitis induced knockout mice exhibited significantly lower levels of MPO activity, histological damage scores, and SP receptor endocytosis than wild-type mice. Inflammatory parameters were significantly reduced by acid inhibition and capsazepine in wild-type mice. CONCLUSIONS: We conclude that acute acid induced oesophagitis is reduced in animals lacking VR-1. This suggests that acid induced oesophagitis may act through VR-1 and that inhibition of the receptor may reduce inflammation.

Duke Scholars

Published In

Gut

DOI

ISSN

0017-5749

Publication Date

January 2006

Volume

55

Issue

1

Start / End Page

34 / 40

Location

England

Related Subject Headings

  • TRPV Cation Channels
  • Severity of Illness Index
  • Receptors, Neurokinin-1
  • Peroxidase
  • Omeprazole
  • Microscopy, Confocal
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Fujino, K., de la Fuente, S. G., Takami, Y., Takahashi, T., & Mantyh, C. R. (2006). Attenuation of acid induced oesophagitis in VR-1 deficient mice. Gut, 55(1), 34–40. https://doi.org/10.1136/gut.2005.066795
Fujino, K., S. G. de la Fuente, Y. Takami, T. Takahashi, and C. R. Mantyh. “Attenuation of acid induced oesophagitis in VR-1 deficient mice.Gut 55, no. 1 (January 2006): 34–40. https://doi.org/10.1136/gut.2005.066795.
Fujino K, de la Fuente SG, Takami Y, Takahashi T, Mantyh CR. Attenuation of acid induced oesophagitis in VR-1 deficient mice. Gut. 2006 Jan;55(1):34–40.
Fujino, K., et al. “Attenuation of acid induced oesophagitis in VR-1 deficient mice.Gut, vol. 55, no. 1, Jan. 2006, pp. 34–40. Pubmed, doi:10.1136/gut.2005.066795.
Fujino K, de la Fuente SG, Takami Y, Takahashi T, Mantyh CR. Attenuation of acid induced oesophagitis in VR-1 deficient mice. Gut. 2006 Jan;55(1):34–40.

Published In

Gut

DOI

ISSN

0017-5749

Publication Date

January 2006

Volume

55

Issue

1

Start / End Page

34 / 40

Location

England

Related Subject Headings

  • TRPV Cation Channels
  • Severity of Illness Index
  • Receptors, Neurokinin-1
  • Peroxidase
  • Omeprazole
  • Microscopy, Confocal
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male