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Characterization of the serum In(Lu)-related antigen: identification of a serum protein related to erythrocyte p80.

Publication ,  Journal Article
Lucas, MG; Green, AM; Telen, MJ
Published in: Blood
February 1989

The In(Lu) gene has been shown previously to downregulate expression by erythrocytes and by a subset of leukocytes of an 80-Kd protein antigen defined by monoclonal antibody (MoAb) A3D8. A3D8 antibody has also been shown by inhibition studies to recognize a serum antigen; this serum antigen is present in reduced amount in serum from In(Lu) donors. The present study demonstrates that the serum antigen recognized by A3D8 antibody also resides on a protein similar in size to the protein present in erythrocyte membranes. Studies using chromatographically purified protein have further shown that this antigen shares many epitopes with that present in RBCs and is therefore likely to be extremely homologous or identical to the erythrocyte In(Lu)-related p80.

Duke Scholars

Published In

Blood

ISSN

0006-4971

Publication Date

February 1989

Volume

73

Issue

2

Start / End Page

596 / 600

Location

United States

Related Subject Headings

  • Molecular Weight
  • Mice
  • Membrane Proteins
  • Lutheran Blood-Group System
  • Immunology
  • Humans
  • Erythrocyte Membrane
  • Blood Proteins
  • Binding Sites, Antibody
  • Antibodies, Monoclonal
 

Citation

APA
Chicago
ICMJE
MLA
NLM

Published In

Blood

ISSN

0006-4971

Publication Date

February 1989

Volume

73

Issue

2

Start / End Page

596 / 600

Location

United States

Related Subject Headings

  • Molecular Weight
  • Mice
  • Membrane Proteins
  • Lutheran Blood-Group System
  • Immunology
  • Humans
  • Erythrocyte Membrane
  • Blood Proteins
  • Binding Sites, Antibody
  • Antibodies, Monoclonal