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A case report: IgG autoanti-N as a cause of severe autoimmune hemolytic anemia.

Publication ,  Journal Article
Combs, MR; Telen, MJ; Hall, SE; Rosse, WF
Published in: Immunohematology
1990

A 21-year-old white worn was referred for evaluation of hemolytic anemia after a 9-day history of marked hemoglobinuria, jaundice, and weakness. The patient's hematocrit was 18%, despite at least eight transfusions over the previous week, and the reticulocyte count was < 1%. Serologic evaluation revealed a weakly positive direct antiglobulin test with anti-C3 only The serum contained cold and warm-reacting anti-N Dithiothreitol had no effect on either the cold- or the warm-reacting anti-N activity, and radioimmunoassay with monoclonal anti-IgG was strongly positive, indicating that both the cold- and the warm-reacting anti-N reactivity resided in the IgG fraction. The patient was treated with N - 'N' + red cell transfusions, prednisone, and azathioprine and gradually became transfusion independent. Postrecovery typing revealed her red cells to be M+N+S+s+. This constitutes the third case of autoimmune hemolytic anemia associated with IgG autoanti-N. The marked hemoglobinuria and reticulocytopenia are unique features of this case.

Duke Scholars

Published In

Immunohematology

ISSN

0894-203X

Publication Date

1990

Volume

6

Issue

4

Start / End Page

83 / 86

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology
 

Citation

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ICMJE
MLA
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Combs, M. R., Telen, M. J., Hall, S. E., & Rosse, W. F. (1990). A case report: IgG autoanti-N as a cause of severe autoimmune hemolytic anemia. Immunohematology, 6(4), 83–86.
Combs, M. R., M. J. Telen, S. E. Hall, and W. F. Rosse. “A case report: IgG autoanti-N as a cause of severe autoimmune hemolytic anemia.Immunohematology 6, no. 4 (1990): 83–86.
Combs MR, Telen MJ, Hall SE, Rosse WF. A case report: IgG autoanti-N as a cause of severe autoimmune hemolytic anemia. Immunohematology. 1990;6(4):83–6.
Combs, M. R., et al. “A case report: IgG autoanti-N as a cause of severe autoimmune hemolytic anemia.Immunohematology, vol. 6, no. 4, 1990, pp. 83–86.
Combs MR, Telen MJ, Hall SE, Rosse WF. A case report: IgG autoanti-N as a cause of severe autoimmune hemolytic anemia. Immunohematology. 1990;6(4):83–86.

Published In

Immunohematology

ISSN

0894-203X

Publication Date

1990

Volume

6

Issue

4

Start / End Page

83 / 86

Location

United States

Related Subject Headings

  • Cardiovascular System & Hematology