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Human red cell antigens. V. Expression of In(Lu)-related p80 antigens by recessive-type Lu(a-b-) red cells.

Publication ,  Journal Article
Telen, MJ; Green, AM
Published in: Transfusion
1988

The In(Lu) gene, which inhibits the expression of Lutheran blood group antigens by red cells (RBCs), also down-regulates the expression of an 80-kD glycoprotein, In(Lu)-related p80, by both RBCs and a subset of white cells. This study examined the expression of multiple-RBC p80 epitopes by autosomal and X-linked recessive-type Lu(a-b-) RBCs in order to explore the relationship, if any, between expression of In(Lu)-related p80 and Lutheran antigens. Both autosomal and X-linked types of recessive Lu(a-b-) RBCs expressed near-normal to increased amounts of p80 antigens, as measured by radioimmunoassay. P80 from both types of recessive Lu(a-b-) RBCs had apparently normal molecular weight in denaturing polyacrylamide gels and showed normal sensitivity to digestion by trypsin and chymotrypsin. Thus, the absence of Lutheran antigens on recessive-type Lu(a-b-) RBCs is not associated with decreased or absent p80 antigens. Furthermore, the XS2 gene probably does not act via a mechanism similar to that of the In(Lu) gene, since the expression of p80 remains undiminished in X-linked recessive-type Lu(a-b-) RBCs.

Duke Scholars

Published In

Transfusion

DOI

ISSN

0041-1132

Publication Date

1988

Volume

28

Issue

5

Start / End Page

430 / 434

Location

United States

Related Subject Headings

  • X Chromosome
  • Neoplasm Proteins
  • Lutheran Blood-Group System
  • Humans
  • Genes, Recessive
  • Cardiovascular System & Hematology
  • 3204 Immunology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1107 Immunology
 

Citation

APA
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ICMJE
MLA
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Telen, M. J., & Green, A. M. (1988). Human red cell antigens. V. Expression of In(Lu)-related p80 antigens by recessive-type Lu(a-b-) red cells. Transfusion, 28(5), 430–434. https://doi.org/10.1046/j.1537-2995.1988.28588337330.x
Telen, M. J., and A. M. Green. “Human red cell antigens. V. Expression of In(Lu)-related p80 antigens by recessive-type Lu(a-b-) red cells.Transfusion 28, no. 5 (1988): 430–34. https://doi.org/10.1046/j.1537-2995.1988.28588337330.x.
Telen, M. J., and A. M. Green. “Human red cell antigens. V. Expression of In(Lu)-related p80 antigens by recessive-type Lu(a-b-) red cells.Transfusion, vol. 28, no. 5, 1988, pp. 430–34. Pubmed, doi:10.1046/j.1537-2995.1988.28588337330.x.
Journal cover image

Published In

Transfusion

DOI

ISSN

0041-1132

Publication Date

1988

Volume

28

Issue

5

Start / End Page

430 / 434

Location

United States

Related Subject Headings

  • X Chromosome
  • Neoplasm Proteins
  • Lutheran Blood-Group System
  • Humans
  • Genes, Recessive
  • Cardiovascular System & Hematology
  • 3204 Immunology
  • 3202 Clinical sciences
  • 3201 Cardiovascular medicine and haematology
  • 1107 Immunology