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Collecting duct carcinoma of the kidney.

Publication ,  Journal Article
Kennedy, SM; Merino, MJ; Linehan, WM; Roberts, JR; Robertson, CN; Neumann, RD
Published in: Hum Pathol
April 1990

Collecting duct carcinoma is an unusual variant of renal cell carcinoma, whose appearance and behavior are not well established. We identified six cases of collecting duct carcinoma in our files. The clinical, pathologic, and immunohistochemical characteristics of these tumors are reported. The most common symptom was gross hematuria (four cases). Two patients had cervical adenopathy due to metastatic tumor. Four rapidly developed systemic metastases and died within 4 to 24 months. The primary renal tumors were located predominantly in the renal medulla and pelvis and had a partially cystic white-gray appearance. Histologic examination showed prominent tubulopapillary structures, nests of clear cells, and infiltrating tubules in a dense desmoplastic stroma. Atypical hyperplastic changes were found in some of the adjacent collecting ducts. Mucicarminophilic material was present in glandular elements in all six cases. Immunohistochemical studies revealed positivity with antibodies to epithelial membrane antigen, keratins, peanut agglutinin, vimentin, Leu M1 and lysozyme. The location of this tumor in the medulla, its distinctive histologic appearance, mucin positivity, expression of high molecular weight cytokeratins, and peanut agglutinin suggest that this is a distinct clinicopathologic entity which has an aggressive clinical course.

Duke Scholars

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

April 1990

Volume

21

Issue

4

Start / End Page

449 / 456

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Humans
  • Female
  • Carcinoma, Renal Cell
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Kennedy, S. M., Merino, M. J., Linehan, W. M., Roberts, J. R., Robertson, C. N., & Neumann, R. D. (1990). Collecting duct carcinoma of the kidney. Hum Pathol, 21(4), 449–456. https://doi.org/10.1016/0046-8177(90)90209-n
Kennedy, S. M., M. J. Merino, W. M. Linehan, J. R. Roberts, C. N. Robertson, and R. D. Neumann. “Collecting duct carcinoma of the kidney.Hum Pathol 21, no. 4 (April 1990): 449–56. https://doi.org/10.1016/0046-8177(90)90209-n.
Kennedy SM, Merino MJ, Linehan WM, Roberts JR, Robertson CN, Neumann RD. Collecting duct carcinoma of the kidney. Hum Pathol. 1990 Apr;21(4):449–56.
Kennedy, S. M., et al. “Collecting duct carcinoma of the kidney.Hum Pathol, vol. 21, no. 4, Apr. 1990, pp. 449–56. Pubmed, doi:10.1016/0046-8177(90)90209-n.
Kennedy SM, Merino MJ, Linehan WM, Roberts JR, Robertson CN, Neumann RD. Collecting duct carcinoma of the kidney. Hum Pathol. 1990 Apr;21(4):449–456.
Journal cover image

Published In

Hum Pathol

DOI

ISSN

0046-8177

Publication Date

April 1990

Volume

21

Issue

4

Start / End Page

449 / 456

Location

United States

Related Subject Headings

  • Pathology
  • Middle Aged
  • Male
  • Kidney Neoplasms
  • Humans
  • Female
  • Carcinoma, Renal Cell
  • Adult
  • 3202 Clinical sciences
  • 1103 Clinical Sciences