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Herpes simplex retinitis in the mouse. Clinicopathologic correlations.

Publication ,  Journal Article
Cousins, SW; Gonzalez, A; Atherton, SS
Published in: Invest Ophthalmol Vis Sci
July 1989

BALB/c mice inoculated with herpes simplex virus type 1 in one anterior chamber develop retinitis with subsequent retinal necrosis in the contralateral eye. The clinical features of this disease were characterized with indirect ophthalmoscopy and fundus photography. Three phases of the disease were delineated: (1) acute retinitis; (2) retinal necrosis; and (3) resolution; the clinical findings in each phase were correlated with the microscopic features. In addition, we compared the virus titers from individual animals with and without clinical evidence of retinitis to demonstrate that retinal inflammation correlated with the titer of virus in the uninoculated eye. This animal model is useful for the analysis of the clinical, virologic and immunologic manifestations of herpetic retinitis.

Duke Scholars

Published In

Invest Ophthalmol Vis Sci

ISSN

0146-0404

Publication Date

July 1989

Volume

30

Issue

7

Start / End Page

1485 / 1494

Location

United States

Related Subject Headings

  • Time Factors
  • Simplexvirus
  • Retinitis
  • Photography
  • Ophthalmology & Optometry
  • Necrosis
  • Mice, Inbred BALB C
  • Mice
  • Herpes Simplex
  • Fundus Oculi
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Cousins, S. W., Gonzalez, A., & Atherton, S. S. (1989). Herpes simplex retinitis in the mouse. Clinicopathologic correlations. Invest Ophthalmol Vis Sci, 30(7), 1485–1494.
Cousins, S. W., A. Gonzalez, and S. S. Atherton. “Herpes simplex retinitis in the mouse. Clinicopathologic correlations.Invest Ophthalmol Vis Sci 30, no. 7 (July 1989): 1485–94.
Cousins SW, Gonzalez A, Atherton SS. Herpes simplex retinitis in the mouse. Clinicopathologic correlations. Invest Ophthalmol Vis Sci. 1989 Jul;30(7):1485–94.
Cousins, S. W., et al. “Herpes simplex retinitis in the mouse. Clinicopathologic correlations.Invest Ophthalmol Vis Sci, vol. 30, no. 7, July 1989, pp. 1485–94.
Cousins SW, Gonzalez A, Atherton SS. Herpes simplex retinitis in the mouse. Clinicopathologic correlations. Invest Ophthalmol Vis Sci. 1989 Jul;30(7):1485–1494.

Published In

Invest Ophthalmol Vis Sci

ISSN

0146-0404

Publication Date

July 1989

Volume

30

Issue

7

Start / End Page

1485 / 1494

Location

United States

Related Subject Headings

  • Time Factors
  • Simplexvirus
  • Retinitis
  • Photography
  • Ophthalmology & Optometry
  • Necrosis
  • Mice, Inbred BALB C
  • Mice
  • Herpes Simplex
  • Fundus Oculi