The DRiP hypothesis decennial: support, controversy, refinement and extension.
Publication
, Journal Article
Yewdell, JW; Nicchitta, CV
Published in: Trends Immunol
August 2006
In 1996, to explain the rapid presentation of viral proteins to CD8+ T cells, it was proposed that peptides presented by MHC class I molecules derive from defective ribosomal products (DRiPs), presumed to be polypeptides arising from in-frame translation that fail to achieve native structure owing to inevitable imperfections in transcription, translation, post-translational modifications or protein folding. Here, we consider findings that address the DRiP hypothesis, and extend the hypothesis by proposing that cells possess specialized machinery, possibly in the form of "immunoribosomes", to couple protein synthesis to antigen presentation.
Duke Scholars
Published In
Trends Immunol
DOI
ISSN
1471-4906
Publication Date
August 2006
Volume
27
Issue
8
Start / End Page
368 / 373
Location
England
Related Subject Headings
- T-Lymphocytes
- Ribosomes
- Ribosomal Proteins
- Models, Biological
- Immunology
- Humans
- Histocompatibility Antigens Class I
- Antigen Presentation
- Animals
- 3204 Immunology
Citation
APA
Chicago
ICMJE
MLA
NLM
Yewdell, J. W., & Nicchitta, C. V. (2006). The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol, 27(8), 368–373. https://doi.org/10.1016/j.it.2006.06.008
Yewdell, Jonathan W., and Christopher V. Nicchitta. “The DRiP hypothesis decennial: support, controversy, refinement and extension.” Trends Immunol 27, no. 8 (August 2006): 368–73. https://doi.org/10.1016/j.it.2006.06.008.
Yewdell JW, Nicchitta CV. The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol. 2006 Aug;27(8):368–73.
Yewdell, Jonathan W., and Christopher V. Nicchitta. “The DRiP hypothesis decennial: support, controversy, refinement and extension.” Trends Immunol, vol. 27, no. 8, Aug. 2006, pp. 368–73. Pubmed, doi:10.1016/j.it.2006.06.008.
Yewdell JW, Nicchitta CV. The DRiP hypothesis decennial: support, controversy, refinement and extension. Trends Immunol. 2006 Aug;27(8):368–373.
Published In
Trends Immunol
DOI
ISSN
1471-4906
Publication Date
August 2006
Volume
27
Issue
8
Start / End Page
368 / 373
Location
England
Related Subject Headings
- T-Lymphocytes
- Ribosomes
- Ribosomal Proteins
- Models, Biological
- Immunology
- Humans
- Histocompatibility Antigens Class I
- Antigen Presentation
- Animals
- 3204 Immunology