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Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses.

Publication ,  Journal Article
Staats, HF; Montgomery, SP; Palker, TJ
Published in: AIDS Res Hum Retroviruses
July 20, 1997

Vaginal anti-HIV antibody responses may be beneficial, and possibly required, for vaccine-induced protection against HIV infection acquired through receptive vaginal intercourse. We have previously determined that intranasal immunization with a hybrid HIV peptide and cholera toxin induced vaginal anti-HIV IgA responses in BALB/c and C57BL/6 mice. To determine if vaginal, gastric, or rectal boosting would enhance the induction of vaginal anti-HIV IgA responses over those observed with intranasal immunization only, C57BL/6 mice were intranasally immunized with the hybrid HIV peptide T1SP10MN(A) and cholera toxin (days 0 and 14) and boosted via the vaginal, gastric, or rectal route (days 7 and 28). Four intranasal immunizations was superior to all other immunizations evaluated for the induction of plasma anti-peptide IgG, vaginal anti-peptide IgG and IgA, and peptide-specific delayed-type hypersensitivity. In addition, intranasal priming with gastric boosting was associated with greatly elevated total serum IgE concentrations whereas intranasal immunization only was associated with only a modest increase in total serum IgE. These results suggest that intranasal immunization is a viable route of immunization for the induction of systemic and mucosal anti-HIV immune responses.

Duke Scholars

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Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

July 20, 1997

Volume

13

Issue

11

Start / End Page

945 / 952

Location

United States

Related Subject Headings

  • Virology
  • Vagina
  • Vaccination
  • Stomach
  • Rectum
  • Peptide Fragments
  • Mucous Membrane
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice
 

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Staats, H. F., Montgomery, S. P., & Palker, T. J. (1997). Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses. AIDS Res Hum Retroviruses, 13(11), 945–952. https://doi.org/10.1089/aid.1997.13.945
Staats, H. F., S. P. Montgomery, and T. J. Palker. “Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses.AIDS Res Hum Retroviruses 13, no. 11 (July 20, 1997): 945–52. https://doi.org/10.1089/aid.1997.13.945.
Staats, H. F., et al. “Intranasal immunization is superior to vaginal, gastric, or rectal immunization for the induction of systemic and mucosal anti-HIV antibody responses.AIDS Res Hum Retroviruses, vol. 13, no. 11, July 1997, pp. 945–52. Pubmed, doi:10.1089/aid.1997.13.945.
Journal cover image

Published In

AIDS Res Hum Retroviruses

DOI

ISSN

0889-2229

Publication Date

July 20, 1997

Volume

13

Issue

11

Start / End Page

945 / 952

Location

United States

Related Subject Headings

  • Virology
  • Vagina
  • Vaccination
  • Stomach
  • Rectum
  • Peptide Fragments
  • Mucous Membrane
  • Molecular Sequence Data
  • Mice, Inbred C57BL
  • Mice