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Systematic gene mapping in man: data management considerations.

Publication ,  Journal Article
Pericak-Vance, MA; Hung, WY; Yamaoka, L; Haynes, C; Bartlett, RJ; Vance, JM; Lee, J; Siddique, T; Gaskell, PC; Stajich, J
Published in: Aust Paediatr J
1988

The application of recombinant DNA technology to linkage analysis is revolutionizing the gene mapping field through the availability of an increasing number of restriction fragment length polymorphisms (RFLP). The successful mapping of the human genome will lead to a new era of research in human genetics with implications for carrier detection and prenatal diagnosis in any number of disorders. In addition, the development of RFLP tightly linked to a disease is critical for the potential identification of the genetic defect. A systematic approach to human gene mapping whereby it is possible to simultaneously screen several disorders for linkage is discussed. Guidelines for the database management, field studies, DNA and lymphoblast cell transformation, family history and laboratory data are included. This methodology represents the integration and application of statistical and molecular genetic, clinical and tissue culture expertise to human gene mapping.

Duke Scholars

Published In

Aust Paediatr J

ISSN

0004-993X

Publication Date

1988

Volume

24 Suppl 1

Start / End Page

87 / 89

Location

Australia

Related Subject Headings

  • Software
  • Polymorphism, Restriction Fragment Length
  • Pedigree
  • Neuromuscular Diseases
  • Information Systems
  • Humans
  • Genetic Linkage
  • DNA
  • Chromosome Mapping
  • Chromosome Disorders
 

Citation

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Pericak-Vance, M. A., Hung, W. Y., Yamaoka, L., Haynes, C., Bartlett, R. J., Vance, J. M., … Stajich, J. (1988). Systematic gene mapping in man: data management considerations. Aust Paediatr J, 24 Suppl 1, 87–89.
Pericak-Vance, M. A., W. Y. Hung, L. Yamaoka, C. Haynes, R. J. Bartlett, J. M. Vance, J. Lee, T. Siddique, P. C. Gaskell, and J. Stajich. “Systematic gene mapping in man: data management considerations.Aust Paediatr J 24 Suppl 1 (1988): 87–89.
Pericak-Vance MA, Hung WY, Yamaoka L, Haynes C, Bartlett RJ, Vance JM, et al. Systematic gene mapping in man: data management considerations. Aust Paediatr J. 1988;24 Suppl 1:87–9.
Pericak-Vance, M. A., et al. “Systematic gene mapping in man: data management considerations.Aust Paediatr J, vol. 24 Suppl 1, 1988, pp. 87–89.
Pericak-Vance MA, Hung WY, Yamaoka L, Haynes C, Bartlett RJ, Vance JM, Lee J, Siddique T, Gaskell PC, Stajich J. Systematic gene mapping in man: data management considerations. Aust Paediatr J. 1988;24 Suppl 1:87–89.

Published In

Aust Paediatr J

ISSN

0004-993X

Publication Date

1988

Volume

24 Suppl 1

Start / End Page

87 / 89

Location

Australia

Related Subject Headings

  • Software
  • Polymorphism, Restriction Fragment Length
  • Pedigree
  • Neuromuscular Diseases
  • Information Systems
  • Humans
  • Genetic Linkage
  • DNA
  • Chromosome Mapping
  • Chromosome Disorders