Skip to main content
Journal cover image

A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019.

Publication ,  Journal Article
Lee, WR; DeSilvio, M; Lawton, C; Gillin, M; Morton, G; Firat, S; Baikadi, M; Kuettel, M; Greven, K; Sandler, H
Published in: Int J Radiat Oncol Biol Phys
March 1, 2006

PURPOSE: To estimate the rate of acute and late Grade 3-5 genitourinary and gastrointestinal toxicity after treatment with external beam radiotherapy and permanent source brachytherapy in a multi-institutional, cooperative group setting. METHODS AND MATERIALS: All patients were treated with external beam radiotherapy (45 Gy in 25 fractions), followed 2-6 weeks later by an interstitial implant using 125I to deliver an additional 108 Gy. Late genitourinary toxicity was graded according to the Common Toxicity Criteria Version 2.0, and the Radiation Therapy Oncology Group/European Organization for Research and Treatment of Cancer late radiation morbidity scoring system was used for all other toxicity. RESULTS: A total of 138 patients from 28 institutions were entered on this study. Acute toxicity information was available in 131 patients, and 127 patients were analyzable for late toxicity. Acute Grade 3 toxicity was documented in 10 of 131 patients (7.6%). No Grade 4 or 5 acute toxicity has been observed. The 18-month month estimate of late Grade 3 genitourinary and gastrointestinal toxicity was 3.3% (95% confidence interval, 0.1-6.5). No late Grade 4 or 5 toxicity has been observed. CONCLUSIONS: The acute and late morbidity observed in this multi-institutional, cooperative group study is consistent with previous reports from single institutions with significant prostate brachytherapy experience.

Duke Scholars

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

March 1, 2006

Volume

64

Issue

3

Start / End Page

804 / 809

Location

United States

Related Subject Headings

  • Urogenital System
  • Radiotherapy Dosage
  • Radiotherapy
  • Radiation Injuries
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Iodine Radioisotopes
  • Humans
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lee, W. R., DeSilvio, M., Lawton, C., Gillin, M., Morton, G., Firat, S., … Sandler, H. (2006). A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019. Int J Radiat Oncol Biol Phys, 64(3), 804–809. https://doi.org/10.1016/j.ijrobp.2005.09.002
Lee, W Robert, Michelle DeSilvio, Colleen Lawton, Michael Gillin, Gerard Morton, Selim Firat, Madhava Baikadi, Michael Kuettel, Kathryn Greven, and Howard Sandler. “A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019.Int J Radiat Oncol Biol Phys 64, no. 3 (March 1, 2006): 804–9. https://doi.org/10.1016/j.ijrobp.2005.09.002.
Lee, W. Robert, et al. “A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019.Int J Radiat Oncol Biol Phys, vol. 64, no. 3, Mar. 2006, pp. 804–09. Pubmed, doi:10.1016/j.ijrobp.2005.09.002.
Lee WR, DeSilvio M, Lawton C, Gillin M, Morton G, Firat S, Baikadi M, Kuettel M, Greven K, Sandler H. A phase II study of external beam radiotherapy combined with permanent source brachytherapy for intermediate-risk, clinically localized adenocarcinoma of the prostate: preliminary results of RTOG P-0019. Int J Radiat Oncol Biol Phys. 2006 Mar 1;64(3):804–809.
Journal cover image

Published In

Int J Radiat Oncol Biol Phys

DOI

ISSN

0360-3016

Publication Date

March 1, 2006

Volume

64

Issue

3

Start / End Page

804 / 809

Location

United States

Related Subject Headings

  • Urogenital System
  • Radiotherapy Dosage
  • Radiotherapy
  • Radiation Injuries
  • Prostatic Neoplasms
  • Oncology & Carcinogenesis
  • Middle Aged
  • Male
  • Iodine Radioisotopes
  • Humans