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CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I.

Publication ,  Journal Article
Tomaras, GD; Greenberg, ML
Published in: Front Biosci
March 1, 2001

The development of cellular immune responses in primary human immunodeficiency virus type-1 (HIV-1) infection is accompanied by a dramatic decrease in plasma viremia and resolution of the acute clinical syndrome. The full nature of the immunological response and its consequences on HIV pathogenesis is still largely a mystery, but significant progress has been achieved in the characterization of some of the players involved. Several studies indicate that noncytolytic HIV suppression by CD8+ T lymphocytes may be inversely associated with viral load suggesting that this antiviral activity is important in host control of HIV replication. This review focuses on this antiviral activity by CD8+ T lymphocytes, which is distinct from that activity elicited by some cytolytic CD8+ T lymphocytes (CTLs).

Duke Scholars

Published In

Front Biosci

DOI

ISSN

1093-9946

Publication Date

March 1, 2001

Volume

6

Start / End Page

D575 / D598

Location

United States

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Humans
  • HIV-1
  • HIV Infections
  • Disease Models, Animal
  • CD8-Positive T-Lymphocytes
  • Biochemistry & Molecular Biology
  • Animals
 

Citation

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Tomaras, G. D., & Greenberg, M. L. (2001). CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I. Front Biosci, 6, D575–D598. https://doi.org/10.2741/tomaras
Tomaras, G. D., and M. L. Greenberg. “CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I.Front Biosci 6 (March 1, 2001): D575–98. https://doi.org/10.2741/tomaras.
Tomaras GD, Greenberg ML. CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I. Front Biosci. 2001 Mar 1;6:D575–98.
Tomaras, G. D., and M. L. Greenberg. “CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I.Front Biosci, vol. 6, Mar. 2001, pp. D575–98. Pubmed, doi:10.2741/tomaras.
Tomaras GD, Greenberg ML. CD8+ T cell mediated noncytolytic inhibition of human immunodeficiency virus type I. Front Biosci. 2001 Mar 1;6:D575–D598.

Published In

Front Biosci

DOI

ISSN

1093-9946

Publication Date

March 1, 2001

Volume

6

Start / End Page

D575 / D598

Location

United States

Related Subject Headings

  • Simian immunodeficiency virus
  • Simian Immunodeficiency Virus
  • Simian Acquired Immunodeficiency Syndrome
  • Humans
  • HIV-1
  • HIV Infections
  • Disease Models, Animal
  • CD8-Positive T-Lymphocytes
  • Biochemistry & Molecular Biology
  • Animals