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Electron transfer between cofactors in protein domains linked by a flexible tether

Publication ,  Journal Article
Kawatsu, T; Beratan, DN
Published in: Chemical Physics
July 11, 2006

Some key electron-transfer (ET) proteins have domains containing redox cofactors connected by a flexible tether. The relative motion of the domains is essential for reaction because of the strong ET rate dependence on distance. The constrained conformational flexibility produces a kinetic regime intermediate between "unimolecular" and "bimolecular". We used a simple model for ET coupled to conformational diffusion to explore the structure dependence of the ET kinetics. The model describes the evolution of an initially prepared reduced donor state, and recovers the diffusion and electron tunneling-limited regimes. The restriction of the conformational space imposed by the tether introduces an entropic component to the effective donor-acceptor interaction potential. As such, the tether length may control the transition between the electron tunneling and diffusion-limited regimes. © 2006 Elsevier B.V. All rights reserved.

Duke Scholars

Published In

Chemical Physics

DOI

ISSN

0301-0104

Publication Date

July 11, 2006

Volume

326

Issue

1

Start / End Page

259 / 269

Related Subject Headings

  • Chemical Physics
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences
 

Citation

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Kawatsu, T., & Beratan, D. N. (2006). Electron transfer between cofactors in protein domains linked by a flexible tether. Chemical Physics, 326(1), 259–269. https://doi.org/10.1016/j.chemphys.2006.01.020
Kawatsu, T., and D. N. Beratan. “Electron transfer between cofactors in protein domains linked by a flexible tether.” Chemical Physics 326, no. 1 (July 11, 2006): 259–69. https://doi.org/10.1016/j.chemphys.2006.01.020.
Kawatsu T, Beratan DN. Electron transfer between cofactors in protein domains linked by a flexible tether. Chemical Physics. 2006 Jul 11;326(1):259–69.
Kawatsu, T., and D. N. Beratan. “Electron transfer between cofactors in protein domains linked by a flexible tether.” Chemical Physics, vol. 326, no. 1, July 2006, pp. 259–69. Scopus, doi:10.1016/j.chemphys.2006.01.020.
Kawatsu T, Beratan DN. Electron transfer between cofactors in protein domains linked by a flexible tether. Chemical Physics. 2006 Jul 11;326(1):259–269.
Journal cover image

Published In

Chemical Physics

DOI

ISSN

0301-0104

Publication Date

July 11, 2006

Volume

326

Issue

1

Start / End Page

259 / 269

Related Subject Headings

  • Chemical Physics
  • 51 Physical sciences
  • 40 Engineering
  • 34 Chemical sciences
  • 09 Engineering
  • 03 Chemical Sciences
  • 02 Physical Sciences