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Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.

Publication ,  Journal Article
Petrella, JR; Coleman, RE; Doraiswamy, PM
Published in: Radiology
February 2003

Alzheimer disease (AD), a progressive neurodegenerative disorder, is the most common cause of dementia in the elderly. Current consensus statements have emphasized the need for early recognition and the fact that a diagnosis of AD can be made with high accuracy by using clinical, neuropsychologic, and imaging assessments. Magnetic resonance (MR) or computed tomographic (CT) imaging is recommended for the routine evaluation of AD. Coronal MR images can be useful to document or quantify atrophy of the hippocampus and entorhinal cortex, both of which occur early in the disease process. Both volumetric and subtraction MR techniques can be used to quantify and monitor dementia progression and rates of regional atrophy. MR measures are also increasingly being used to monitor treatment effects in clinical trials of cognitive enhancers and antidementia agents. Positron emission tomography (PET) and single photon emission CT offer value in the differential diagnosis of AD from other cortical and subcortical dementias and may also offer prognostic value. In addition, PET studies have demonstrated that subtle abnormalities may be apparent in the prodromal stages of AD and in subjects who carry susceptibility genes. PET ligands are in late-stage development for demonstration of amyloid plaques, and human studies have already begun. Functional MR-based memory challenge tests are in development as well.

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Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

February 2003

Volume

226

Issue

2

Start / End Page

315 / 336

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, Emission-Computed
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Diagnostic Imaging
  • Diagnosis, Differential
  • Alzheimer Disease
 

Citation

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Petrella, J. R., Coleman, R. E., & Doraiswamy, P. M. (2003). Neuroimaging and early diagnosis of Alzheimer disease: a look to the future. Radiology, 226(2), 315–336. https://doi.org/10.1148/radiol.2262011600
Petrella, Jeffrey R., R Edward Coleman, and P Murali Doraiswamy. “Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.Radiology 226, no. 2 (February 2003): 315–36. https://doi.org/10.1148/radiol.2262011600.
Petrella JR, Coleman RE, Doraiswamy PM. Neuroimaging and early diagnosis of Alzheimer disease: a look to the future. Radiology. 2003 Feb;226(2):315–36.
Petrella, Jeffrey R., et al. “Neuroimaging and early diagnosis of Alzheimer disease: a look to the future.Radiology, vol. 226, no. 2, Feb. 2003, pp. 315–36. Pubmed, doi:10.1148/radiol.2262011600.
Petrella JR, Coleman RE, Doraiswamy PM. Neuroimaging and early diagnosis of Alzheimer disease: a look to the future. Radiology. 2003 Feb;226(2):315–336.
Journal cover image

Published In

Radiology

DOI

ISSN

0033-8419

Publication Date

February 2003

Volume

226

Issue

2

Start / End Page

315 / 336

Location

United States

Related Subject Headings

  • Tomography, X-Ray Computed
  • Tomography, Emission-Computed, Single-Photon
  • Tomography, Emission-Computed
  • Predictive Value of Tests
  • Nuclear Medicine & Medical Imaging
  • Magnetic Resonance Imaging
  • Humans
  • Diagnostic Imaging
  • Diagnosis, Differential
  • Alzheimer Disease