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Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.

Publication ,  Journal Article
Sandstrom, CK; Krishnan, S; Slavin, MJ; Tran, T-TT; Doraiswamy, PM; Petrella, JR
Published in: AJNR Am J Neuroradiol
September 2006

BACKGROUND AND PURPOSE: Functional MR imaging has been used to study patterns of hippocampal activation that distinguish pathologic from normal memory loss in the elderly population. Our objective was to assess whether hippocampal atrophy confounds measurements of hippocampal activation in subjects with mild cognitive impairment (MCI). METHODS: Twenty subjects with MCI and 20 elderly control subjects with objectively normal memory were studied at 4T during a face-name paradigm designed to activate the hippocampus. Hippocampal activation was measured using 2 separate approaches: applying a preset region of interest (ROI) in standardized template space and applying a manually drawn ROI in native subject space. Pearson correlation coefficients were calculated to compare group-dependent relationships between hippocampal volume and activation. Analysis of covariance (ANCOVA) was performed to assess group differences in hippocampal activation during encoding and retrieval. Age and hippocampal volume were included as covariates, as was a term for the interaction between hippocampal volume and group. RESULTS: When hippocampal activation was measured by the template-based method, the correlation coefficient in the right hippocampus of subjects with MCI but not control subjects during retrieval differed significantly from zero. There was a significant (P < .05) group-by-volume interaction in the ANCOVA model. No significant correlations or interactions were demonstrated when activation was measured in native subject space with manually drawn ROIs. CONCLUSION: Our findings suggest a potential confounding relationship between hippocampal volume and activation for subjects with MCI in template-based analyses. Template-based measures of hippocampal activation that do not adequately account for hippocampal atrophy should be used with caution in patients with MCI.

Duke Scholars

Published In

AJNR Am J Neuroradiol

ISSN

0195-6108

Publication Date

September 2006

Volume

27

Issue

8

Start / End Page

1622 / 1627

Location

United States

Related Subject Headings

  • Verbal Learning
  • Software
  • Reference Values
  • Pattern Recognition, Visual
  • Nuclear Medicine & Medical Imaging
  • Neuropsychological Tests
  • Middle Aged
  • Mental Status Schedule
  • Mental Recall
  • Mathematical Computing
 

Citation

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MLA
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Sandstrom, C. K., Krishnan, S., Slavin, M. J., Tran, T.-T., Doraiswamy, P. M., & Petrella, J. R. (2006). Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment. AJNR Am J Neuroradiol, 27(8), 1622–1627.
Sandstrom, C. K., S. Krishnan, M. J. Slavin, T. -. T. T. Tran, P. M. Doraiswamy, and J. R. Petrella. “Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.AJNR Am J Neuroradiol 27, no. 8 (September 2006): 1622–27.
Sandstrom CK, Krishnan S, Slavin MJ, Tran T-TT, Doraiswamy PM, Petrella JR. Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment. AJNR Am J Neuroradiol. 2006 Sep;27(8):1622–7.
Sandstrom, C. K., et al. “Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment.AJNR Am J Neuroradiol, vol. 27, no. 8, Sept. 2006, pp. 1622–27.
Sandstrom CK, Krishnan S, Slavin MJ, Tran T-TT, Doraiswamy PM, Petrella JR. Hippocampal atrophy confounds template-based functional MR imaging measures of hippocampal activation in patients with mild cognitive impairment. AJNR Am J Neuroradiol. 2006 Sep;27(8):1622–1627.

Published In

AJNR Am J Neuroradiol

ISSN

0195-6108

Publication Date

September 2006

Volume

27

Issue

8

Start / End Page

1622 / 1627

Location

United States

Related Subject Headings

  • Verbal Learning
  • Software
  • Reference Values
  • Pattern Recognition, Visual
  • Nuclear Medicine & Medical Imaging
  • Neuropsychological Tests
  • Middle Aged
  • Mental Status Schedule
  • Mental Recall
  • Mathematical Computing