Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.
Publication
, Journal Article
Majumder, PK; Yeh, JJ; George, DJ; Febbo, PG; Kum, J; Xue, Q; Bikoff, R; Ma, H; Kantoff, PW; Golub, TR; Loda, M; Sellers, WR
Published in: Proc Natl Acad Sci U S A
June 24, 2003
To determine whether Akt activation was sufficient for the transformation of normal prostate epithelial cells, murine prostate restricted Akt kinase activity was generated in transgenic mice (MPAKT mice). Akt expression led to p70S6K activation, prostatic intraepithelial neoplasia (PIN), and bladder obstruction. mRNA expression profiles from MPAKT ventral prostate revealed similarities to human cancer and an angiogenic signature that included three angiogenin family members, one of which was found elevated in the plasma of men with prostate cancer. Thus, the MPAKT model may be useful in studying the role of Akt in prostate epithelial cell transformation and in the discovery of molecular markers relevant to human disease.
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Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
June 24, 2003
Volume
100
Issue
13
Start / End Page
7841 / 7846
Location
United States
Related Subject Headings
- Urinary Bladder
- Transgenes
- Ribosomal Protein S6 Kinases, 70-kDa
- RNA, Messenger
- RNA
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins
- Protein Serine-Threonine Kinases
- Prostatic Intraepithelial Neoplasia
- Prostate
Citation
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Majumder, P. K., Yeh, J. J., George, D. J., Febbo, P. G., Kum, J., Xue, Q., … Sellers, W. R. (2003). Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A, 100(13), 7841–7846. https://doi.org/10.1073/pnas.1232229100
Majumder, Pradip K., Jen Jen Yeh, Daniel J. George, Phillip G. Febbo, Jennifer Kum, Qi Xue, Rachel Bikoff, et al. “Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.” Proc Natl Acad Sci U S A 100, no. 13 (June 24, 2003): 7841–46. https://doi.org/10.1073/pnas.1232229100.
Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, et al. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7841–6.
Majumder, Pradip K., et al. “Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model.” Proc Natl Acad Sci U S A, vol. 100, no. 13, June 2003, pp. 7841–46. Pubmed, doi:10.1073/pnas.1232229100.
Majumder PK, Yeh JJ, George DJ, Febbo PG, Kum J, Xue Q, Bikoff R, Ma H, Kantoff PW, Golub TR, Loda M, Sellers WR. Prostate intraepithelial neoplasia induced by prostate restricted Akt activation: the MPAKT model. Proc Natl Acad Sci U S A. 2003 Jun 24;100(13):7841–7846.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
June 24, 2003
Volume
100
Issue
13
Start / End Page
7841 / 7846
Location
United States
Related Subject Headings
- Urinary Bladder
- Transgenes
- Ribosomal Protein S6 Kinases, 70-kDa
- RNA, Messenger
- RNA
- Proto-Oncogene Proteins c-akt
- Proto-Oncogene Proteins
- Protein Serine-Threonine Kinases
- Prostatic Intraepithelial Neoplasia
- Prostate