Role of phosphoinositide 3-kinase in cardiac function and heart failure.
Publication
, Journal Article
Naga Prasad, SV; Perrino, C; Rockman, HA
Published in: Trends Cardiovasc Med
July 2003
Phosphoinositide 3-kinase (PI3K) belongs to a conserved family of lipid kinases that regulate many critical functions in the cell by generating 3'-phosphorylated phosphatidylinositols. Although PI3K has been the focus of intense study in various biologic processes including apoptosis, metastasis, and neuronal differentiation, it is only recently that the focus has shifted to understanding the role of PI3K in cardiac function, hypertrophy, and heart failure. This article reviews the role of PI3K in regulating cardiac growth, contractility, beta-adrenergic receptor function, and hypertrophy, as well as possible novel therapeutic strategies in the treatment of heart failure.
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Published In
Trends Cardiovasc Med
DOI
ISSN
1050-1738
Publication Date
July 2003
Volume
13
Issue
5
Start / End Page
206 / 212
Location
United States
Related Subject Headings
- Phosphatidylinositol 3-Kinases
- Humans
- Heart Failure
- Heart
- Cardiovascular System & Hematology
- Cardiomegaly
- Apoptosis
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology
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Naga Prasad, S. V., Perrino, C., & Rockman, H. A. (2003). Role of phosphoinositide 3-kinase in cardiac function and heart failure. Trends Cardiovasc Med, 13(5), 206–212. https://doi.org/10.1016/s1050-1738(03)00080-x
Naga Prasad, Sathyamangla V., Cinzia Perrino, and Howard A. Rockman. “Role of phosphoinositide 3-kinase in cardiac function and heart failure.” Trends Cardiovasc Med 13, no. 5 (July 2003): 206–12. https://doi.org/10.1016/s1050-1738(03)00080-x.
Naga Prasad SV, Perrino C, Rockman HA. Role of phosphoinositide 3-kinase in cardiac function and heart failure. Trends Cardiovasc Med. 2003 Jul;13(5):206–12.
Naga Prasad, Sathyamangla V., et al. “Role of phosphoinositide 3-kinase in cardiac function and heart failure.” Trends Cardiovasc Med, vol. 13, no. 5, July 2003, pp. 206–12. Pubmed, doi:10.1016/s1050-1738(03)00080-x.
Naga Prasad SV, Perrino C, Rockman HA. Role of phosphoinositide 3-kinase in cardiac function and heart failure. Trends Cardiovasc Med. 2003 Jul;13(5):206–212.
Published In
Trends Cardiovasc Med
DOI
ISSN
1050-1738
Publication Date
July 2003
Volume
13
Issue
5
Start / End Page
206 / 212
Location
United States
Related Subject Headings
- Phosphatidylinositol 3-Kinases
- Humans
- Heart Failure
- Heart
- Cardiovascular System & Hematology
- Cardiomegaly
- Apoptosis
- 3201 Cardiovascular medicine and haematology
- 1102 Cardiorespiratory Medicine and Haematology