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Alteration and restoration of K+ channel function by deletions at the N- and C-termini.

Publication ,  Journal Article
VanDongen, AM; Frech, GC; Drewe, JA; Joho, RH; Brown, AM
Published in: Neuron
October 1990

Voltage-dependent ion channels are thought to consist of a highly conserved repeated core of six transmembrane segments, flanked by more variable cytoplasmic domains. Significant functional differences exist among related types of K+ channels. These differences have been attributed to the variable domains, most prominently the N- and C-termini. We have therefore investigated the functional importance of both termini for the delayed rectifier K+ channel from rat brain encoded by the drk1 gene. This channel has an unusually long C-terminus. Deletions in either terminus affected both activation and inactivation, in some cases profoundly. Unexpectedly, more extensive deletions in both termini restored gating. We could therefore define a core region only slightly longer than the six transmembrane segments that is sufficient for the formation of channels with the kinetics of a delayed rectifier.

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Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

October 1990

Volume

5

Issue

4

Start / End Page

433 / 443

Location

United States

Related Subject Headings

  • Rats
  • Potassium Channels
  • Neurology & Neurosurgery
  • Mutation
  • Kinetics
  • Ion Channel Gating
  • Electrophysiology
  • Chromosome Deletion
  • Brain
  • Animals
 

Citation

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VanDongen, A. M., Frech, G. C., Drewe, J. A., Joho, R. H., & Brown, A. M. (1990). Alteration and restoration of K+ channel function by deletions at the N- and C-termini. Neuron, 5(4), 433–443. https://doi.org/10.1016/0896-6273(90)90082-q
VanDongen, A. M., G. C. Frech, J. A. Drewe, R. H. Joho, and A. M. Brown. “Alteration and restoration of K+ channel function by deletions at the N- and C-termini.Neuron 5, no. 4 (October 1990): 433–43. https://doi.org/10.1016/0896-6273(90)90082-q.
VanDongen AM, Frech GC, Drewe JA, Joho RH, Brown AM. Alteration and restoration of K+ channel function by deletions at the N- and C-termini. Neuron. 1990 Oct;5(4):433–43.
VanDongen, A. M., et al. “Alteration and restoration of K+ channel function by deletions at the N- and C-termini.Neuron, vol. 5, no. 4, Oct. 1990, pp. 433–43. Pubmed, doi:10.1016/0896-6273(90)90082-q.
VanDongen AM, Frech GC, Drewe JA, Joho RH, Brown AM. Alteration and restoration of K+ channel function by deletions at the N- and C-termini. Neuron. 1990 Oct;5(4):433–443.
Journal cover image

Published In

Neuron

DOI

ISSN

0896-6273

Publication Date

October 1990

Volume

5

Issue

4

Start / End Page

433 / 443

Location

United States

Related Subject Headings

  • Rats
  • Potassium Channels
  • Neurology & Neurosurgery
  • Mutation
  • Kinetics
  • Ion Channel Gating
  • Electrophysiology
  • Chromosome Deletion
  • Brain
  • Animals