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Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis?

Publication ,  Journal Article
Hoffman, M; Monroe, DM; Roubey, RA
Published in: Immunol Res
2000

Inflammation and immune activation have been associated with thrombosis in a number of settings. We have been interested in the question of how the presence of a type of autoantibody, so-called "antiphospholipid" antibody, leads to thrombosis. Several mechanisms have been proposed including modulation of tissue factor expression, enhancement of procoagulant binding to platelets, and interference with antithrombotic mechanisms. We developed a cell-based model of coagulation that, unlike current coagulation assays, reflects some of the in vivo activities of "antiphospholipid" antibodies. "Antiphospholipid" antibodies against the phospholipid-binding protein beta-2-glycoprotein-1 enhance thrombin generation in this model system, primarily by enhancing procoagulant reactions on tissue factor-bearing cells.

Duke Scholars

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2000

Volume

22

Issue

2-3

Start / End Page

191 / 197

Location

United States

Related Subject Headings

  • beta-Thromboglobulin
  • Thrombosis
  • Thrombin
  • Monocytes
  • Immunology
  • Humans
  • Blood Coagulation
  • Antibodies, Antiphospholipid
  • 3204 Immunology
  • 1107 Immunology
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Hoffman, M., Monroe, D. M., & Roubey, R. A. (2000). Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis? Immunol Res, 22(2–3), 191–197. https://doi.org/10.1385/IR:22:2-3:191
Hoffman, M., D. M. Monroe, and R. A. Roubey. “Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis?Immunol Res 22, no. 2–3 (2000): 191–97. https://doi.org/10.1385/IR:22:2-3:191.
Hoffman M, Monroe DM, Roubey RA. Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis? Immunol Res. 2000;22(2–3):191–7.
Hoffman, M., et al. “Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis?Immunol Res, vol. 22, no. 2–3, 2000, pp. 191–97. Pubmed, doi:10.1385/IR:22:2-3:191.
Hoffman M, Monroe DM, Roubey RA. Links between the immune and coagulation systems: how do "antiphospholipid antibodies" cause thrombosis? Immunol Res. 2000;22(2–3):191–197.
Journal cover image

Published In

Immunol Res

DOI

ISSN

0257-277X

Publication Date

2000

Volume

22

Issue

2-3

Start / End Page

191 / 197

Location

United States

Related Subject Headings

  • beta-Thromboglobulin
  • Thrombosis
  • Thrombin
  • Monocytes
  • Immunology
  • Humans
  • Blood Coagulation
  • Antibodies, Antiphospholipid
  • 3204 Immunology
  • 1107 Immunology