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Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog.

Publication ,  Journal Article
Daniel, TM; Pizzo, SV; Mckee, PA
Published in: Ann Surg
August 1976

An experimental model of surgically-induced arterial thrombosis was devised using the femoral arteries of dogs. Within 7 days, 67% of the arteries became completely thrombosed and only 12% remained compeletly patent. In the group of dogs that received low-dose heparin, 69% of the vessels were completely thrombosed and 6% remained completely patent. In the group of dogs treated with low-dose Ancrod to induce partial defibrination, 75% remained completely patent while only 19% of their femoral arteries were completely thrombosed. Although the ancrod was effective in preventing arterial thrombosis, 88% of the wounds showed moderate to severe separations. Most likely the absence of a fibrin lattice, necessary for the securement and growth of fibroblasts as the wound heals, explains this latter effect. Thus while Ancrod may become useful as an anticoagulant in certain clinical situations, it should not be used in proximity to surgery. Finally, in these studies of acute arterial thromboses, low-dose heparin therapy offered no protective effect.

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Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

August 1976

Volume

184

Issue

2

Start / End Page

223 / 228

Location

United States

Related Subject Headings

  • Wound Healing
  • Thrombosis
  • Surgery
  • Heparin
  • Fibrinogen
  • Fibrin Fibrinogen Degradation Products
  • Femoral Artery
  • Endopeptidases
  • Endarterectomy
  • Dogs
 

Citation

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Daniel, T. M., Pizzo, S. V., & Mckee, P. A. (1976). Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog. Ann Surg, 184(2), 223–228. https://doi.org/10.1097/00000658-197608000-00015
Daniel, T. M., S. V. Pizzo, and P. A. Mckee. “Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog.Ann Surg 184, no. 2 (August 1976): 223–28. https://doi.org/10.1097/00000658-197608000-00015.
Daniel TM, Pizzo SV, Mckee PA. Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog. Ann Surg. 1976 Aug;184(2):223–8.
Daniel, T. M., et al. “Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog.Ann Surg, vol. 184, no. 2, Aug. 1976, pp. 223–28. Pubmed, doi:10.1097/00000658-197608000-00015.
Daniel TM, Pizzo SV, Mckee PA. Comparison of ancrod and heparin as anticoagulants following endarterectomy in the dog. Ann Surg. 1976 Aug;184(2):223–228.

Published In

Ann Surg

DOI

ISSN

0003-4932

Publication Date

August 1976

Volume

184

Issue

2

Start / End Page

223 / 228

Location

United States

Related Subject Headings

  • Wound Healing
  • Thrombosis
  • Surgery
  • Heparin
  • Fibrinogen
  • Fibrin Fibrinogen Degradation Products
  • Femoral Artery
  • Endopeptidases
  • Endarterectomy
  • Dogs