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In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.

Publication ,  Journal Article
Shorr, RI; Kao, KJ; Pizzo, SV; Rauckman, EJ; Rosen, GM
Published in: Thromb Res
April 1, 1985

We examined the effect of acetaminophen and the structural analogues 2,6-dimethylacetaminophen, 3,5-dimethylacetaminophen, and N-acetyl-p-benzoquinone imine on human platelet aggregation, 14C-serotonin secretion, and thromboxane B2 synthesis. Preincubation with 1 mM acetaminophen for 2 min completely inhibited arachidonic acid- and collagen-stimulated platelet aggregation. Thromboxane B2 production and 14C-serotonin secretion by arachidonic acid-stimulated platelets also were completely inhibited. Preincubation of platelets with 1 mM 3,5-dimethylacetaminophen inhibited collagen and arachidonic acid-induced aggregation and arachidonic acid-stimulated thromboxane B2 synthesis, while treatment with 2,6-dimethylacetaminophen did not inhibit aggregation and blocked thromboxane B2 formation to a much lesser degree. Preincubation with 1 mM N-acetyl-p-benzoquinone imine inhibited arachidonic acid-induced aggregation and 14C-serotonin secretion but had no effect on arachidonic acid-induced thromboxane B2 formation and collagen-induced platelet aggregation.

Duke Scholars

Published In

Thromb Res

DOI

ISSN

0049-3848

Publication Date

April 1, 1985

Volume

38

Issue

1

Start / End Page

33 / 43

Location

United States

Related Subject Headings

  • Thromboxanes
  • Thromboxane B2
  • Serotonin
  • Platelet Aggregation
  • Humans
  • Cardiovascular System & Hematology
  • Arachidonic Acids
  • Arachidonic Acid
  • Acetaminophen
  • 3202 Clinical sciences
 

Citation

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Shorr, R. I., Kao, K. J., Pizzo, S. V., Rauckman, E. J., & Rosen, G. M. (1985). In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. Thromb Res, 38(1), 33–43. https://doi.org/10.1016/0049-3848(85)90005-2
Shorr, R. I., K. J. Kao, S. V. Pizzo, E. J. Rauckman, and G. M. Rosen. “In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.Thromb Res 38, no. 1 (April 1, 1985): 33–43. https://doi.org/10.1016/0049-3848(85)90005-2.
Shorr RI, Kao KJ, Pizzo SV, Rauckman EJ, Rosen GM. In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. Thromb Res. 1985 Apr 1;38(1):33–43.
Shorr, R. I., et al. “In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis.Thromb Res, vol. 38, no. 1, Apr. 1985, pp. 33–43. Pubmed, doi:10.1016/0049-3848(85)90005-2.
Shorr RI, Kao KJ, Pizzo SV, Rauckman EJ, Rosen GM. In vitro effects of acetaminophen and its analogues on human platelet aggregation and thromboxane B2 synthesis. Thromb Res. 1985 Apr 1;38(1):33–43.
Journal cover image

Published In

Thromb Res

DOI

ISSN

0049-3848

Publication Date

April 1, 1985

Volume

38

Issue

1

Start / End Page

33 / 43

Location

United States

Related Subject Headings

  • Thromboxanes
  • Thromboxane B2
  • Serotonin
  • Platelet Aggregation
  • Humans
  • Cardiovascular System & Hematology
  • Arachidonic Acids
  • Arachidonic Acid
  • Acetaminophen
  • 3202 Clinical sciences