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Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats.

Publication ,  Journal Article
Goldstein, LB; Bullman, S
Published in: Neurorehabil Neural Repair
December 2002

BACKGROUND: A variety of drugs impair motor recovery after sensorimotor cortex (SMCTX) injury in laboratory animals and may have similar effects in humans. METHODS: Rats (n = 142) underwent unilateral suction-ablation of the hindlimb SMCTX or sham lesion. After 24 hours, rats were given a single dose of placebo, haloperidol (0.1, 1.0, or 10.0 mg/kg, intraperitoneal), or clozapine (0.1, 0.5, 1.0, or 10.0 mg/kg, intraperitoneal), and motor recovery was measured. RESULTS: Neither haloperidol (analysis of variance [ANOVA] F[3, 12], P = 0.43) nor clozapine (ANOVA F[4, 19], P = 1.00) affected motor performance in controls. Haloperidol impaired motor recovery (ANOVA F[3, 42], P = 0.002) at each tested dose, with no differences between the doses. The effect persisted after 2 weeks. In contrast, although rats given a single dose of clozapine of 1.0 or 10.0 mg/kg had poorer recoveries (ANOVA F[4, 51], P = 0.014), only those given the highest dose differed from controls. The effect was no longer apparent after 2 weeks. CONCLUSION: Consistent with previous reports, haloperidol retards motor recovery after SMCTX injury in rats. In contrast, there was no detrimental effect of clozapine when given at low doses. The use of low doses of atypical antipsychotics such as clozapine may provide a safer alternative to haloperidol in the treatment of agitated stroke patients.

Duke Scholars

Published In

Neurorehabil Neural Repair

DOI

ISSN

1545-9683

Publication Date

December 2002

Volume

16

Issue

4

Start / End Page

321 / 325

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Serotonin Antagonists
  • Rehabilitation
  • Rats, Sprague-Dawley
  • Rats
  • Motor Activity
  • Male
  • Haloperidol
  • Dose-Response Relationship, Drug
  • Dopamine Antagonists
 

Citation

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Goldstein, L. B., & Bullman, S. (2002). Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats. Neurorehabil Neural Repair, 16(4), 321–325. https://doi.org/10.1177/154596830201600402
Goldstein, Larry B., and Sarah Bullman. “Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats.Neurorehabil Neural Repair 16, no. 4 (December 2002): 321–25. https://doi.org/10.1177/154596830201600402.
Goldstein LB, Bullman S. Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats. Neurorehabil Neural Repair. 2002 Dec;16(4):321–5.
Goldstein, Larry B., and Sarah Bullman. “Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats.Neurorehabil Neural Repair, vol. 16, no. 4, Dec. 2002, pp. 321–25. Pubmed, doi:10.1177/154596830201600402.
Goldstein LB, Bullman S. Differential effects of haloperidol and clozapine on motor recovery after sensorimotor cortex injury in rats. Neurorehabil Neural Repair. 2002 Dec;16(4):321–325.
Journal cover image

Published In

Neurorehabil Neural Repair

DOI

ISSN

1545-9683

Publication Date

December 2002

Volume

16

Issue

4

Start / End Page

321 / 325

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Serotonin Antagonists
  • Rehabilitation
  • Rats, Sprague-Dawley
  • Rats
  • Motor Activity
  • Male
  • Haloperidol
  • Dose-Response Relationship, Drug
  • Dopamine Antagonists