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Neurotransmitters and motor activity: effects on functional recovery after brain injury.

Publication ,  Journal Article
Goldstein, LB
Published in: NeuroRx
October 2006

There are complex relationships among behavioral experience, brain morphology, and functional recovery of an animal before and after brain injury. A large series of experimental studies have shown that exogenous manipulation of central neurotransmitter levels can directly affect plastic changes in the brain and can modulate the effects of experience and training. These complex relationships provide a formidable challenge for studies aimed at understanding neurotransmitter effects on the recovery process. Experiments delineating norepinephrine-modulated locomotor recovery after injury to the cerebral cortex illustrate the close relationships among neurotransmitter levels, brain plasticity, and behavioral recovery. Understanding the neurobiological processes underlying recovery, and how they might be manipulated, may lead to novel strategies for improving recovery from stroke-related gait impairment in humans.

Duke Scholars

Published In

NeuroRx

DOI

ISSN

1545-5343

Publication Date

October 2006

Volume

3

Issue

4

Start / End Page

451 / 457

Location

United States

Related Subject Headings

  • Sympathomimetics
  • Norepinephrine
  • Neurotransmitter Agents
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Motor Activity
  • Locomotion
  • Humans
  • Brain Injuries
  • Animals
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goldstein, L. B. (2006). Neurotransmitters and motor activity: effects on functional recovery after brain injury. NeuroRx, 3(4), 451–457. https://doi.org/10.1016/j.nurx.2006.07.010
Goldstein, Larry B. “Neurotransmitters and motor activity: effects on functional recovery after brain injury.NeuroRx 3, no. 4 (October 2006): 451–57. https://doi.org/10.1016/j.nurx.2006.07.010.
Goldstein, Larry B. “Neurotransmitters and motor activity: effects on functional recovery after brain injury.NeuroRx, vol. 3, no. 4, Oct. 2006, pp. 451–57. Pubmed, doi:10.1016/j.nurx.2006.07.010.
Journal cover image

Published In

NeuroRx

DOI

ISSN

1545-5343

Publication Date

October 2006

Volume

3

Issue

4

Start / End Page

451 / 457

Location

United States

Related Subject Headings

  • Sympathomimetics
  • Norepinephrine
  • Neurotransmitter Agents
  • Neuronal Plasticity
  • Neurology & Neurosurgery
  • Motor Activity
  • Locomotion
  • Humans
  • Brain Injuries
  • Animals