Skip to main content
Journal cover image

Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction.

Publication ,  Journal Article
Serebruany, VL; Gurbel, PA; Shustov, AR; Ohman, EM; Topol, EJ
Published in: Am Heart J
September 1998

BACKGROUND: Platelets play an important role in the natural history of acute myocardial infarction (AMI). METHODS AND RESULTS: Platelet aggregation and receptor expression were studied in 23 patients with AMI before reperfusion therapy and compared with 10 healthy control subjects. Platelet aggregation was induced with 5 micromol/L adenosine 5'-diphosphate, 10 micromol/L ADP, 1 microg/mL collagen, 1 mg/mL thrombin, and 1.25 mg/mL ristocetin. Receptor expression was measured by flow cytometry with monoclonal antibodies to p24 (CD9), Ib (CD42b), IIb (CD41b), IIIa (CD61), IIb/IIIa (CD41b/CD61), very late antigen-2 (CD49b), P-selectin (CD62p), platelet/endothelial cell adhesion molecule-1 (CD31); and vitronectin (CD51/CD61). The percentage of platelet aggregation was higher in patients with AMI when induced by 5 micromol/L ADP (64.1+/-12.7 vs 52.0+/-6.7; P=.04), by 10 micromol/L ADP (71.7+/-13.0 vs 59.2+/-7.2, P=.003), by thrombin (75.8+/-10.9 vs 60.5+/-6.9, P=.01), and by ristocetin (92.5+/-7.8 vs 71.3+/-7.4, P=.0001). Collagen-induced platelet aggregation did not differ between groups. Expression of P-selectin (log amplification of fluorescence intensity) (31.5+/-5.0 vs 25.1+/-2.6, P=.003) and platelet/endothelial cell adhesion molecule-1 (56.8+/-17.7 vs 44.5+/-3.7, P=.04) were significantly increased in patients with AMI. The expression of IIb (28.4+/-2.5 vs 37.2+/-1.7, P=.0001) and Ib (103.6+/-29.9 vs 133.8+/-8.0, P=.007) were reduced in patients with AMI. CONCLUSIONS: Platelets are not necessarily systemically activated during the prereperfusion phase of AMI. For each agonist used and surface antigen measured, there was a cohort of patients with AMI within the normal or even below normal range of platelet status.

Duke Scholars

Altmetric Attention Stats
Dimensions Citation Stats

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

September 1998

Volume

136

Issue

3

Start / End Page

398 / 405

Location

United States

Related Subject Headings

  • Thrombin
  • Ristocetin
  • Receptors, Cytoadhesin
  • Receptors, Cell Surface
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Platelet Aggregation
  • P-Selectin
  • Myocardial Infarction
  • Middle Aged
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Serebruany, V. L., Gurbel, P. A., Shustov, A. R., Ohman, E. M., & Topol, E. J. (1998). Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction. Am Heart J, 136(3), 398–405. https://doi.org/10.1016/s0002-8703(98)70212-1
Serebruany, V. L., P. A. Gurbel, A. R. Shustov, E. M. Ohman, and E. J. Topol. “Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction.Am Heart J 136, no. 3 (September 1998): 398–405. https://doi.org/10.1016/s0002-8703(98)70212-1.
Serebruany VL, Gurbel PA, Shustov AR, Ohman EM, Topol EJ. Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction. Am Heart J. 1998 Sep;136(3):398–405.
Serebruany, V. L., et al. “Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction.Am Heart J, vol. 136, no. 3, Sept. 1998, pp. 398–405. Pubmed, doi:10.1016/s0002-8703(98)70212-1.
Serebruany VL, Gurbel PA, Shustov AR, Ohman EM, Topol EJ. Heterogeneity of platelet aggregation and major surface receptor expression in patients with acute myocardial infarction. Am Heart J. 1998 Sep;136(3):398–405.
Journal cover image

Published In

Am Heart J

DOI

ISSN

0002-8703

Publication Date

September 1998

Volume

136

Issue

3

Start / End Page

398 / 405

Location

United States

Related Subject Headings

  • Thrombin
  • Ristocetin
  • Receptors, Cytoadhesin
  • Receptors, Cell Surface
  • Platelet Endothelial Cell Adhesion Molecule-1
  • Platelet Aggregation
  • P-Selectin
  • Myocardial Infarction
  • Middle Aged
  • Male