Skip to main content
Journal cover image

Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice.

Publication ,  Journal Article
Lewis, DV; Jones, LS; Mott, DD
Published in: Exp Neurol
November 1989

In rat hippocampal slices, low concentrations of (+/-) baclofen (0.1 to 1.5 microM) elicited spontaneous, rhythmic sharp waves (SRSWs). These low amplitude (0.1 to 0.3 mV) SRSWs were visible with high amplification in the extracellular recordings from the CA1, CA2, and CA3 regions and were roughly synchronous in all areas. SRSW amplitude increased and frequency decreased as baclofen concentration increased up to 1.5 microM, but SRSWs were suppressed at concentrations of 5 microM and higher. The amplitude of the SRSWs was greater in the strata radiatum and the lacunosum moleculare than in the stratum pyramidale. (-)-Baclofen was much more potent in eliciting SRSWs than (+)-baclofen. Low concentrations of baclofen also caused the extracellular excitatory postsynaptic potential in the stratum radiatum of CA3b evoked by stimulation of the Schaffer collaterals to broaden and develop a secondary peak. Slices pretreated with pertussis toxin required much higher concentrations of baclofen to elicit the SRSWs, indicating that the baclofen may be eliciting the SRSWs through a G protein-sensitive mechanism. Baclofen has both inhibitory and disinhibitory effects on neurons. The appearance of these spontaneous population events suggests that, at low concentrations, the disinhibitory effects may be more powerful than the inhibitory effects.

Duke Scholars

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

November 1989

Volume

106

Issue

2

Start / End Page

181 / 186

Location

United States

Related Subject Headings

  • Virulence Factors, Bordetella
  • Rats, Inbred Strains
  • Rats
  • Pertussis Toxin
  • Neurology & Neurosurgery
  • Male
  • Hippocampus
  • GTP-Binding Proteins
  • Electrophysiology
  • Dose-Response Relationship, Drug
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Lewis, D. V., Jones, L. S., & Mott, D. D. (1989). Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. Exp Neurol, 106(2), 181–186. https://doi.org/10.1016/0014-4886(89)90092-7
Lewis, D. V., L. S. Jones, and D. D. Mott. “Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice.Exp Neurol 106, no. 2 (November 1989): 181–86. https://doi.org/10.1016/0014-4886(89)90092-7.
Lewis DV, Jones LS, Mott DD. Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. Exp Neurol. 1989 Nov;106(2):181–6.
Lewis, D. V., et al. “Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice.Exp Neurol, vol. 106, no. 2, Nov. 1989, pp. 181–86. Pubmed, doi:10.1016/0014-4886(89)90092-7.
Lewis DV, Jones LS, Mott DD. Baclofen induces spontaneous, rhythmic sharp waves in the rat hippocampal slice. Exp Neurol. 1989 Nov;106(2):181–186.
Journal cover image

Published In

Exp Neurol

DOI

ISSN

0014-4886

Publication Date

November 1989

Volume

106

Issue

2

Start / End Page

181 / 186

Location

United States

Related Subject Headings

  • Virulence Factors, Bordetella
  • Rats, Inbred Strains
  • Rats
  • Pertussis Toxin
  • Neurology & Neurosurgery
  • Male
  • Hippocampus
  • GTP-Binding Proteins
  • Electrophysiology
  • Dose-Response Relationship, Drug