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Deletion of p16 and p15 genes in brain tumors.

Publication ,  Journal Article
Jen, J; Harper, JW; Bigner, SH; Bigner, DD; Papadopoulos, N; Markowitz, S; Willson, JK; Kinzler, KW; Vogelstein, B
Published in: Cancer Res
December 15, 1994

We have used molecular genetic methods to examine the status of cell cycle-inhibitory genes in human brain tumors. We found that p16 and a neighboring gene, p15, were often homozygously deleted in glioblastoma multiformes but not in medulloblastomas or ependymomas. The deletions occurred in both primary tumors and their derived xenografts, but no intragenic mutations in either of the two genes were found. The p15 gene was expressed in a more widespread pattern in normal tissues than p16, but the products of both genes had similar capacities to bind to cyclin D-dependent kinases 4 and 6. These data suggest that the target of deletion in glioblastoma multiforme includes both p15 and p16 genes. The reason that homozygous deletions, rather than intragenic mutations, are so common in these tumors may be that deletion is a more efficient mechanism for simultaneous inactivation of both genes.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

December 15, 1994

Volume

54

Issue

24

Start / End Page

6353 / 6358

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Oncology & Carcinogenesis
  • Molecular Sequence Data
  • Mice, Nude
  • Mice
  • Medulloblastoma
  • Humans
  • Glioblastoma
  • Gene Deletion
  • Ependymoma
 

Citation

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MLA
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Jen, J., Harper, J. W., Bigner, S. H., Bigner, D. D., Papadopoulos, N., Markowitz, S., … Vogelstein, B. (1994). Deletion of p16 and p15 genes in brain tumors. Cancer Res, 54(24), 6353–6358.
Jen, J., J. W. Harper, S. H. Bigner, D. D. Bigner, N. Papadopoulos, S. Markowitz, J. K. Willson, K. W. Kinzler, and B. Vogelstein. “Deletion of p16 and p15 genes in brain tumors.Cancer Res 54, no. 24 (December 15, 1994): 6353–58.
Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, et al. Deletion of p16 and p15 genes in brain tumors. Cancer Res. 1994 Dec 15;54(24):6353–8.
Jen, J., et al. “Deletion of p16 and p15 genes in brain tumors.Cancer Res, vol. 54, no. 24, Dec. 1994, pp. 6353–58.
Jen J, Harper JW, Bigner SH, Bigner DD, Papadopoulos N, Markowitz S, Willson JK, Kinzler KW, Vogelstein B. Deletion of p16 and p15 genes in brain tumors. Cancer Res. 1994 Dec 15;54(24):6353–6358.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

December 15, 1994

Volume

54

Issue

24

Start / End Page

6353 / 6358

Location

United States

Related Subject Headings

  • Transplantation, Heterologous
  • Oncology & Carcinogenesis
  • Molecular Sequence Data
  • Mice, Nude
  • Mice
  • Medulloblastoma
  • Humans
  • Glioblastoma
  • Gene Deletion
  • Ependymoma