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The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats.

Publication ,  Journal Article
Copeland, DD; Bigner, DD
Published in: Acta Neuropathol
April 29, 1977

F-344 rats were inoculated intracerebrally at 1 and at 133 days of age with the Bratislava-77 strain of avian sarcoma virus. Groups of rats were sequentially sacrificed following inoculation so that early stages of microtumor formation could be evaluated. In neonatally inoculated rats incipient tumors developed in the subependymal region of the lateral ventricles in close juxtaposition to clusters of poorly differentiated germinal cells. Among these animals microtumors were detected as soon as 2 weeks after inoculation; by 4 weeks post-inoculation all rats inoculated at 1 day of age had tumors. In contrast among rats inoculated as adults incipient tumors developed in the cerebral cortex away from the subependymal region but adjacent to the locus of inoculation. Incipient tumors were uncommon in rats inoculated as adults during the first 2 months after inoculation.

Duke Scholars

Published In

Acta Neuropathol

DOI

ISSN

0001-6322

Publication Date

April 29, 1977

Volume

38

Issue

1

Start / End Page

1 / 6

Location

Germany

Related Subject Headings

  • Time Factors
  • Sarcoma, Experimental
  • Rats
  • Pregnancy
  • Neurology & Neurosurgery
  • Female
  • Cerebral Ventricles
  • Cerebral Cortex
  • Cell Differentiation
  • Brain Neoplasms
 

Citation

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Copeland, D. D., & Bigner, D. D. (1977). The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats. Acta Neuropathol, 38(1), 1–6. https://doi.org/10.1007/BF00691268
Copeland, D. D., and D. D. Bigner. “The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats.Acta Neuropathol 38, no. 1 (April 29, 1977): 1–6. https://doi.org/10.1007/BF00691268.
Copeland, D. D., and D. D. Bigner. “The role of the subependymal plate in avian sarcoma virus brain tumor induction: comparison of incipient tumors in neonatal and adult rats.Acta Neuropathol, vol. 38, no. 1, Apr. 1977, pp. 1–6. Pubmed, doi:10.1007/BF00691268.
Journal cover image

Published In

Acta Neuropathol

DOI

ISSN

0001-6322

Publication Date

April 29, 1977

Volume

38

Issue

1

Start / End Page

1 / 6

Location

Germany

Related Subject Headings

  • Time Factors
  • Sarcoma, Experimental
  • Rats
  • Pregnancy
  • Neurology & Neurosurgery
  • Female
  • Cerebral Ventricles
  • Cerebral Cortex
  • Cell Differentiation
  • Brain Neoplasms