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Determination of gangliosides in six human primary medulloblastomas.

Publication ,  Journal Article
Gottfries, J; Fredman, P; Månsson, JE; Collins, VP; von Holst, H; Armstrong, DD; Percy, AK; Wikstrand, CJ; Bigner, DD; Svennerholm, L
Published in: J Neurochem
October 1990
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The ganglioside composition of six human medulloblastomas was analyzed. The characterization was performed by thin-layer chromatography, sialidase hydrolysis, and immunological staining with a panel of characterized antiganglioside monoclonal antibodies. The total ganglioside content ranged from 60 to 1,130 nmol of ganglioside sialic acid/g wet weight. Neuronal gangliosides (gangliotetraose series) were found in varying amounts in all medulloblastomas. Gangliosides of the neolactotetraose series (3'-LM1 and LD1) were present in all specimens, and the lactotetraose series ganglioside 3'-isoLM1 was found in all cases showing astrocytic differentiation. This supports our previous findings that 3'-isoLM1 is a marker for proliferating astroglial cells.

Duke Scholars

Darell Doty Bigner
Author Darell Doty Bigner Neurosurgery
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Published In

J Neurochem

DOI

10.1111/j.1471-4159.1990.tb03142.x

ISSN

0022-3042

Publication Date

October 1990

Volume

55

Issue

4

Start / End Page

1322 / 1326

Location

England

Related Subject Headings

  • Sialic Acids
  • Neurology & Neurosurgery
  • Medulloblastoma
  • Male
  • Infant
  • Humans
  • Gangliosides
  • Female
  • Chromatography, Thin Layer
  • Child, Preschool
 

Citation

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Gottfries, J., Fredman, P., Månsson, J. E., Collins, V. P., von Holst, H., Armstrong, D. D., … Svennerholm, L. (1990). Determination of gangliosides in six human primary medulloblastomas. J Neurochem, 55(4), 1322–1326. https://doi.org/10.1111/j.1471-4159.1990.tb03142.x
Gottfries, J., P. Fredman, J. E. Månsson, V. P. Collins, H. von Holst, D. D. Armstrong, A. K. Percy, C. J. Wikstrand, D. D. Bigner, and L. Svennerholm. “Determination of gangliosides in six human primary medulloblastomas.” J Neurochem 55, no. 4 (October 1990): 1322–26. https://doi.org/10.1111/j.1471-4159.1990.tb03142.x.
Gottfries J, Fredman P, Månsson JE, Collins VP, von Holst H, Armstrong DD, et al. Determination of gangliosides in six human primary medulloblastomas. J Neurochem. 1990 Oct;55(4):1322–6.
Gottfries, J., et al. “Determination of gangliosides in six human primary medulloblastomas.” J Neurochem, vol. 55, no. 4, Oct. 1990, pp. 1322–26. Pubmed, doi:10.1111/j.1471-4159.1990.tb03142.x.
Gottfries J, Fredman P, Månsson JE, Collins VP, von Holst H, Armstrong DD, Percy AK, Wikstrand CJ, Bigner DD, Svennerholm L. Determination of gangliosides in six human primary medulloblastomas. J Neurochem. 1990 Oct;55(4):1322–1326.
Journal cover image

Published In

J Neurochem

DOI

10.1111/j.1471-4159.1990.tb03142.x

ISSN

0022-3042

Publication Date

October 1990

Volume

55

Issue

4

Start / End Page

1322 / 1326

Location

England

Related Subject Headings

  • Sialic Acids
  • Neurology & Neurosurgery
  • Medulloblastoma
  • Male
  • Infant
  • Humans
  • Gangliosides
  • Female
  • Chromatography, Thin Layer
  • Child, Preschool