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Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.

Publication ,  Journal Article
Neuwelt, EA; Barnett, PA; Bigner, DD; Frenkel, EP
Published in: Proc Natl Acad Sci U S A
July 1982

The effect of adrenal cortical steroids and osmotic blood-brain barrier modification on methotrexate delivery to normal and glioma-bearing rats was studied. In animals with the avian sarcoma virus-induced glioma, osmotic blood-brain barrier modification resulted in significantly increased delivery of methotrexate to the tumor-bearing hemisphere (including the tumor, the brain around the tumor, and the brain distant to the tumor), compared to the nonmodified hemisphere or to control animals. The administration of adrenal steroids, followed by intracarotid methotrexate, resulted in slightly decreased chemotherapeutic agent (methotrexate) delivery to the tumor, the brain around the tumor, and the brain distant to the tumor. When adrenal steroids were given prior to barrier modification and methotrexate therapy, the level of methotrexate was significantly less in the tumor. These studies provide evidence that the blood-brain barrier exists in tumors and is a factor in drug delivery to tumors. Steroid administration greatly interferes with the enhancement of drug delivery to tumors that can be achieved with osmotic blood-brain barrier modification.

Duke Scholars

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

July 1982

Volume

79

Issue

14

Start / End Page

4420 / 4423

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Neoplasms, Experimental
  • Methotrexate
  • Mannitol
  • Glioma
  • Dexamethasone
  • Brain Neoplasms
  • Brain
  • Blood-Brain Barrier
 

Citation

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Neuwelt, E. A., Barnett, P. A., Bigner, D. D., & Frenkel, E. P. (1982). Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier. Proc Natl Acad Sci U S A, 79(14), 4420–4423. https://doi.org/10.1073/pnas.79.14.4420
Neuwelt, E. A., P. A. Barnett, D. D. Bigner, and E. P. Frenkel. “Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.Proc Natl Acad Sci U S A 79, no. 14 (July 1982): 4420–23. https://doi.org/10.1073/pnas.79.14.4420.
Neuwelt, E. A., et al. “Effects of adrenal cortical steroids and osmotic blood-brain barrier opening on methotrexate delivery to gliomas in the rodent: the factor of the blood-brain barrier.Proc Natl Acad Sci U S A, vol. 79, no. 14, July 1982, pp. 4420–23. Pubmed, doi:10.1073/pnas.79.14.4420.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

ISSN

0027-8424

Publication Date

July 1982

Volume

79

Issue

14

Start / End Page

4420 / 4423

Location

United States

Related Subject Headings

  • Rats, Inbred F344
  • Rats
  • Neoplasms, Experimental
  • Methotrexate
  • Mannitol
  • Glioma
  • Dexamethasone
  • Brain Neoplasms
  • Brain
  • Blood-Brain Barrier