Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations.
Publication
, Journal Article
Bigner, SH; Mark, J; Bullard, DE; Mahaley, MS; Bigner, DD
Published in: Cancer Genet Cytogenet
June 1986
Our previous karyotypic studies of malignant human gliomas have demonstrated that their most consistent early or primary gross changes include gains of #7, losses of #10, #22, and the gonosomes, and the presence of double minutes. Karyotypes of 15 additional malignant human gliomas reported here have confirmed these observations and, by enlarging our series, we can now show that in addition to double minutes, certain other gross structural abnormalities also are clearly associated with the early evolution of this type of tumor. The most prevalent deviations are deletions and translocations involving 9p. Other chromosomes commonly involved in rearrangements are #1, #6, and #13, and less frequently #7, #11, and #16.
Duke Scholars
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Published In
Cancer Genet Cytogenet
DOI
ISSN
0165-4608
Publication Date
June 1986
Volume
22
Issue
2
Start / End Page
121 / 135
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Middle Aged
- Male
- Karyotyping
- Humans
- Glioblastoma
- Female
- Chromosome Aberrations
- Aged
- Adult
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Bigner, S. H., Mark, J., Bullard, D. E., Mahaley, M. S., & Bigner, D. D. (1986). Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations. Cancer Genet Cytogenet, 22(2), 121–135. https://doi.org/10.1016/0165-4608(86)90172-x
Bigner, S. H., J. Mark, D. E. Bullard, M. S. Mahaley, and D. D. Bigner. “Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations.” Cancer Genet Cytogenet 22, no. 2 (June 1986): 121–35. https://doi.org/10.1016/0165-4608(86)90172-x.
Bigner SH, Mark J, Bullard DE, Mahaley MS, Bigner DD. Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations. Cancer Genet Cytogenet. 1986 Jun;22(2):121–35.
Bigner, S. H., et al. “Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations.” Cancer Genet Cytogenet, vol. 22, no. 2, June 1986, pp. 121–35. Pubmed, doi:10.1016/0165-4608(86)90172-x.
Bigner SH, Mark J, Bullard DE, Mahaley MS, Bigner DD. Chromosomal evolution in malignant human gliomas starts with specific and usually numerical deviations. Cancer Genet Cytogenet. 1986 Jun;22(2):121–135.
Published In
Cancer Genet Cytogenet
DOI
ISSN
0165-4608
Publication Date
June 1986
Volume
22
Issue
2
Start / End Page
121 / 135
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Middle Aged
- Male
- Karyotyping
- Humans
- Glioblastoma
- Female
- Chromosome Aberrations
- Aged
- Adult