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Regional measurements of blood flow in experimental RG-2 rat gliomas.

Publication ,  Journal Article
Groothuis, DR; Pasternak, JF; Fischer, JM; Blasberg, RG; Bigner, DD; Vick, NA
Published in: Cancer Res
July 1983

Regional measurements of blood flow (F) were performed in transplanted intracerebral RG-2 rat gliomas using [14C]iodoantipyrine, Kety-Schmidt blood flow equations, and quantitative autoradiography. Twenty-nine intracranial tumors in ten rats were analyzed by location; 18 intraparenchymal, seven meningeal, two third-ventricular, and two fourth-ventricular tumors were studied. For all tumors, averaged mean F was 91 +/- 33 (S.D.) ml/hg/min. In all but one tumor, mean F was intermediate between normal cortex and corpus callosum values. There was moderate regional variation: averaged mean F was lower in tumor center (78 +/- 47 ml/hg/min) than in tumor periphery (93 +/- 30 ml/hg/min). Within individual tumors, F showed moderate variation which correlated to some extent with histological features; a regional F of less than 10 ml/hg/min was observed in only one tumor within an area of necrosis. F in regions of brain immediately surrounding the tumor was higher than in tumor periphery. Blood flow to RG-2 tumors seems unlikely to limit drug delivery any more than to normal brain, and the consistent levels from tumor to tumor and within individual tumors make the RG-2 model an excellent one with which to study drug delivery in experimental brain tumors.

Duke Scholars

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1983

Volume

43

Issue

7

Start / End Page

3362 / 3367

Location

United States

Related Subject Headings

  • Scintillation Counting
  • Regional Blood Flow
  • Rats, Inbred F344
  • Rats
  • Oncology & Carcinogenesis
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • Models, Biological
  • Meningeal Neoplasms
  • Male
 

Citation

APA
Chicago
ICMJE
MLA
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Groothuis, D. R., Pasternak, J. F., Fischer, J. M., Blasberg, R. G., Bigner, D. D., & Vick, N. A. (1983). Regional measurements of blood flow in experimental RG-2 rat gliomas. Cancer Res, 43(7), 3362–3367.
Groothuis, D. R., J. F. Pasternak, J. M. Fischer, R. G. Blasberg, D. D. Bigner, and N. A. Vick. “Regional measurements of blood flow in experimental RG-2 rat gliomas.Cancer Res 43, no. 7 (July 1983): 3362–67.
Groothuis DR, Pasternak JF, Fischer JM, Blasberg RG, Bigner DD, Vick NA. Regional measurements of blood flow in experimental RG-2 rat gliomas. Cancer Res. 1983 Jul;43(7):3362–7.
Groothuis, D. R., et al. “Regional measurements of blood flow in experimental RG-2 rat gliomas.Cancer Res, vol. 43, no. 7, July 1983, pp. 3362–67.
Groothuis DR, Pasternak JF, Fischer JM, Blasberg RG, Bigner DD, Vick NA. Regional measurements of blood flow in experimental RG-2 rat gliomas. Cancer Res. 1983 Jul;43(7):3362–3367.

Published In

Cancer Res

ISSN

0008-5472

Publication Date

July 1983

Volume

43

Issue

7

Start / End Page

3362 / 3367

Location

United States

Related Subject Headings

  • Scintillation Counting
  • Regional Blood Flow
  • Rats, Inbred F344
  • Rats
  • Oncology & Carcinogenesis
  • Neoplasms, Experimental
  • Neoplasm Transplantation
  • Models, Biological
  • Meningeal Neoplasms
  • Male