Skip to main content
Journal cover image

Cognitive dysfunction after cardiac surgery: revisiting etiology.

Publication ,  Journal Article
Grocott, HP; Homi, HM; Puskas, F
Published in: Semin Cardiothorac Vasc Anesth
June 2005

Cognitive dysfunction remains a frequent complication of cardiac surgery. Despite many years of research, few preventive strategies and no definitive therapeutic options exist for the management of this troublesome clinical problem. This shortcoming may be secondary to an incomplete understanding of the pathophysiology and etiology of cognitive loss after cardiac surgery; a better understanding of the etiology is essential to finding new therapies. The etiology of cognitive dysfunction after cardiac surgery is multifactorial and includes cerebral microembolization, global cerebral hypoperfusion, systemic and cerebral inflammation, cerebral temperature perturbations, cerebral edema, and possible blood-brain barrier dysfunction, all superimposed on genetic differences in patients that may make them more susceptible to injury or unable to repair from injury once it has occurred. This review expands on these potential etiologies in detailing the evidence for their existence.

Duke Scholars

Published In

Semin Cardiothorac Vasc Anesth

DOI

ISSN

1089-2532

Publication Date

June 2005

Volume

9

Issue

2

Start / End Page

123 / 129

Location

United States

Related Subject Headings

  • Rewarming
  • Postoperative Complications
  • Intracranial Embolism
  • Hyperthermia, Induced
  • Humans
  • Encephalitis
  • Cognition Disorders
  • Cerebrovascular Disorders
  • Cerebrovascular Circulation
  • Cardiac Surgical Procedures
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Grocott, H. P., Homi, H. M., & Puskas, F. (2005). Cognitive dysfunction after cardiac surgery: revisiting etiology. Semin Cardiothorac Vasc Anesth, 9(2), 123–129. https://doi.org/10.1177/108925320500900204
Grocott, Hilary P., H Mayumi Homi, and Ferenc Puskas. “Cognitive dysfunction after cardiac surgery: revisiting etiology.Semin Cardiothorac Vasc Anesth 9, no. 2 (June 2005): 123–29. https://doi.org/10.1177/108925320500900204.
Grocott HP, Homi HM, Puskas F. Cognitive dysfunction after cardiac surgery: revisiting etiology. Semin Cardiothorac Vasc Anesth. 2005 Jun;9(2):123–9.
Grocott, Hilary P., et al. “Cognitive dysfunction after cardiac surgery: revisiting etiology.Semin Cardiothorac Vasc Anesth, vol. 9, no. 2, June 2005, pp. 123–29. Pubmed, doi:10.1177/108925320500900204.
Grocott HP, Homi HM, Puskas F. Cognitive dysfunction after cardiac surgery: revisiting etiology. Semin Cardiothorac Vasc Anesth. 2005 Jun;9(2):123–129.
Journal cover image

Published In

Semin Cardiothorac Vasc Anesth

DOI

ISSN

1089-2532

Publication Date

June 2005

Volume

9

Issue

2

Start / End Page

123 / 129

Location

United States

Related Subject Headings

  • Rewarming
  • Postoperative Complications
  • Intracranial Embolism
  • Hyperthermia, Induced
  • Humans
  • Encephalitis
  • Cognition Disorders
  • Cerebrovascular Disorders
  • Cerebrovascular Circulation
  • Cardiac Surgical Procedures