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Interleukin 1 receptors and biological responses.

Publication ,  Journal Article
Dinarello, CA; Clark, BD; Ikejima, T; Puren, AJ; Savage, N; Rosoff, PM
Published in: Yale J Biol Med
1990

Interleukin 1 (IL-1) is a polypeptide which possesses a wide variety of biological properties. IL-1 was originally studied as "endogenous pyrogen" and "leukocytic endogenous mediator" and more recently as "lymphocyte activating factor." Within a few minutes after intravenous injection into experimental animals, IL-1 triggers events in the hypothalamus to initiate fever, slow-wave sleep, and the release of a variety of neuropeptides. The nature of the IL-1 receptors (IL-1R) is important to the understanding of IL-1's multiple action in mediating both neural and non-neural events. In this paper, the data are reviewed on the physical nature of the dominant, high-binding 80 kDa IL-1R isolated from murine T cells. In addition, newer studies demonstrate the existence of other IL-1 binding proteins which may participate as functional IL-1 receptors. These are a 68-75 kDa binding protein found on B cells and a 26-30 kDa binding protein found on T cells and mesangial cells. There is a considerable discrepancy between the number and affinities of the 80 kDa IL-1R and biological responses. Little is known about the relationship of the 68-75 or 26-30 kDa IL-R's biological responses. It is possible that, similar to neurotransmitter receptors, multiple chains of different binding proteins participate in the signal transduction of IL-1. The hydrolysis of non-phosphatidyl inositol membrane phospholipids plays an important role in responses to IL-1.

Duke Scholars

Published In

Yale J Biol Med

ISSN

0044-0086

Publication Date

1990

Volume

63

Issue

2

Start / End Page

87 / 93

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Interleukin-1
  • Receptors, Immunologic
  • Gastroenterology & Hepatology
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences
 

Citation

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Dinarello, C. A., Clark, B. D., Ikejima, T., Puren, A. J., Savage, N., & Rosoff, P. M. (1990). Interleukin 1 receptors and biological responses. Yale J Biol Med, 63(2), 87–93.
Dinarello, C. A., B. D. Clark, T. Ikejima, A. J. Puren, N. Savage, and P. M. Rosoff. “Interleukin 1 receptors and biological responses.Yale J Biol Med 63, no. 2 (1990): 87–93.
Dinarello CA, Clark BD, Ikejima T, Puren AJ, Savage N, Rosoff PM. Interleukin 1 receptors and biological responses. Yale J Biol Med. 1990;63(2):87–93.
Dinarello, C. A., et al. “Interleukin 1 receptors and biological responses.Yale J Biol Med, vol. 63, no. 2, 1990, pp. 87–93.
Dinarello CA, Clark BD, Ikejima T, Puren AJ, Savage N, Rosoff PM. Interleukin 1 receptors and biological responses. Yale J Biol Med. 1990;63(2):87–93.

Published In

Yale J Biol Med

ISSN

0044-0086

Publication Date

1990

Volume

63

Issue

2

Start / End Page

87 / 93

Location

United States

Related Subject Headings

  • Signal Transduction
  • Receptors, Interleukin-1
  • Receptors, Immunologic
  • Gastroenterology & Hepatology
  • Animals
  • 32 Biomedical and clinical sciences
  • 31 Biological sciences