A novel chromosomal rearrangement associated with therapy-related acute leukemia.
Publication
, Journal Article
Powell, J; Traweek, T; Beatty, O; Qumsiyeh, MB; Rosoff, PM
Published in: Cancer Genet Cytogenet
July 15, 1999
We describe a 7-year-old girl with therapy-related acute myeloid leukemia (AML) associated with a single and novel karyotypic abnormality. The patient had been treated with alkylating agents and etoposide for hypothalamic pilocytic astrocytoma at age 17 months, and developed mixed lineage AML. Cytogenetic analysis of the leukemic blasts showed 46,XX,der(7)t(7;11)(q22;q14) in all cells examined. Southern blot analysis revealed three copies of an unrearranged MLL gene on chromosome 11q. This is the first report of a triplicated, unrearranged MLL gene in association with a deletion of 7q anomaly and an unbalanced translocation in therapy-related leukemia.
Duke Scholars
Published In
Cancer Genet Cytogenet
DOI
ISSN
0165-4608
Publication Date
July 15, 1999
Volume
112
Issue
2
Start / End Page
173 / 177
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasms, Second Primary
- Magnetic Resonance Imaging
- Leukemia
- Karyotyping
- Humans
- Female
- Chromosomes, Human, Pair 7
- Chromosomes, Human, Pair 11
- Chromosome Aberrations
Citation
APA
Chicago
ICMJE
MLA
NLM
Powell, J., Traweek, T., Beatty, O., Qumsiyeh, M. B., & Rosoff, P. M. (1999). A novel chromosomal rearrangement associated with therapy-related acute leukemia. Cancer Genet Cytogenet, 112(2), 173–177. https://doi.org/10.1016/s0165-4608(98)00277-5
Powell, J., T. Traweek, O. Beatty, M. B. Qumsiyeh, and P. M. Rosoff. “A novel chromosomal rearrangement associated with therapy-related acute leukemia.” Cancer Genet Cytogenet 112, no. 2 (July 15, 1999): 173–77. https://doi.org/10.1016/s0165-4608(98)00277-5.
Powell J, Traweek T, Beatty O, Qumsiyeh MB, Rosoff PM. A novel chromosomal rearrangement associated with therapy-related acute leukemia. Cancer Genet Cytogenet. 1999 Jul 15;112(2):173–7.
Powell, J., et al. “A novel chromosomal rearrangement associated with therapy-related acute leukemia.” Cancer Genet Cytogenet, vol. 112, no. 2, July 1999, pp. 173–77. Pubmed, doi:10.1016/s0165-4608(98)00277-5.
Powell J, Traweek T, Beatty O, Qumsiyeh MB, Rosoff PM. A novel chromosomal rearrangement associated with therapy-related acute leukemia. Cancer Genet Cytogenet. 1999 Jul 15;112(2):173–177.
Published In
Cancer Genet Cytogenet
DOI
ISSN
0165-4608
Publication Date
July 15, 1999
Volume
112
Issue
2
Start / End Page
173 / 177
Location
United States
Related Subject Headings
- Oncology & Carcinogenesis
- Neoplasms, Second Primary
- Magnetic Resonance Imaging
- Leukemia
- Karyotyping
- Humans
- Female
- Chromosomes, Human, Pair 7
- Chromosomes, Human, Pair 11
- Chromosome Aberrations