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Role of MAP1B in axonal retrograde transport of mitochondria.

Publication ,  Journal Article
Jiménez-Mateos, E-M; González-Billault, C; Dawson, HN; Vitek, MP; Avila, J
Published in: Biochem J
July 1, 2006

The MAPs (microtubule-associated proteins) MAP1B and tau are well known for binding to microtubules and stabilizing these structures. An additional role for MAPs has emerged recently where they appear to participate in the regulation of transport of cargos on the microtubules found in axons. In this role, tau has been associated with the regulation of anterograde axonal transport. We now report that MAP1B is associated with the regulation of retrograde axonal transport of mitochondria. This finding potentially provides precise control of axonal transport by MAPs at several levels: controlling the anterograde or retrograde direction of transport depending on the type of MAP involved, controlling the speed of transport and controlling the stability of the microtubule tracks upon which transport occurs.

Duke Scholars

Published In

Biochem J

DOI

EISSN

1470-8728

Publication Date

July 1, 2006

Volume

397

Issue

1

Start / End Page

53 / 59

Location

England

Related Subject Headings

  • Mitochondria
  • Microtubule-Associated Proteins
  • Mice, Inbred C57BL
  • Mice
  • Hippocampus
  • Cells, Cultured
  • Biochemistry & Molecular Biology
  • Axonal Transport
  • Animals
  • 3101 Biochemistry and cell biology
 

Citation

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Chicago
ICMJE
MLA
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Jiménez-Mateos, E.-M., González-Billault, C., Dawson, H. N., Vitek, M. P., & Avila, J. (2006). Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J, 397(1), 53–59. https://doi.org/10.1042/BJ20060205
Jiménez-Mateos, Eva-María, Christian González-Billault, Hana N. Dawson, Michael P. Vitek, and Jesús Avila. “Role of MAP1B in axonal retrograde transport of mitochondria.Biochem J 397, no. 1 (July 1, 2006): 53–59. https://doi.org/10.1042/BJ20060205.
Jiménez-Mateos E-M, González-Billault C, Dawson HN, Vitek MP, Avila J. Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J. 2006 Jul 1;397(1):53–9.
Jiménez-Mateos, Eva-María, et al. “Role of MAP1B in axonal retrograde transport of mitochondria.Biochem J, vol. 397, no. 1, July 2006, pp. 53–59. Pubmed, doi:10.1042/BJ20060205.
Jiménez-Mateos E-M, González-Billault C, Dawson HN, Vitek MP, Avila J. Role of MAP1B in axonal retrograde transport of mitochondria. Biochem J. 2006 Jul 1;397(1):53–59.

Published In

Biochem J

DOI

EISSN

1470-8728

Publication Date

July 1, 2006

Volume

397

Issue

1

Start / End Page

53 / 59

Location

England

Related Subject Headings

  • Mitochondria
  • Microtubule-Associated Proteins
  • Mice, Inbred C57BL
  • Mice
  • Hippocampus
  • Cells, Cultured
  • Biochemistry & Molecular Biology
  • Axonal Transport
  • Animals
  • 3101 Biochemistry and cell biology