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Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.

Publication ,  Journal Article
Goldstein, LB; Vitek, MP; Dawson, H; Bullman, S
Published in: Neuroscience
2000

Motor recovery after unilateral sensorimotor cortex ablation or sham-injury was measured in apolipoprotein E knockout and wild-type mice by testing their abilities to traverse a narrow beam. All mice trained without difficulty. Sham-operated mice performed perfectly regardless of genotype throughout testing. There was no difference in motor scores between lesioned apolipoprotein E knockout and wild-type mice on a first trial 24h after injury (P>0.05). There was a significant overall effect of lesion on motor performance (two-way repeated measures analysis of variance F(1,42)=304, P<0.0001), a significant time effect (F(17,714)=58, P<0.0001) and a lesion by time interaction (F(17,714)=58, P<0.0001). However, there was no effect of apolipoprotein E genotype group on recovery rate (i.e. there was no lesion group by genotype group by time interaction, F(17,714)=0.33, P=1.00) and no effect of genotype on the final level of motor performance 12 days after the lesion (Kruskal-Wallis H=5.79, P=0.12). These data suggest that motor recovery after unilateral injury to the sensorimotor cortex does not vary with apolipoprotein E genotype.

Duke Scholars

Published In

Neuroscience

DOI

ISSN

0306-4522

Publication Date

2000

Volume

99

Issue

4

Start / End Page

705 / 710

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Recovery of Function
  • Postural Balance
  • Neurology & Neurosurgery
  • Motor Cortex
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Locomotion
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Goldstein, L. B., Vitek, M. P., Dawson, H., & Bullman, S. (2000). Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. Neuroscience, 99(4), 705–710. https://doi.org/10.1016/s0306-4522(00)00234-7
Goldstein, L. B., M. P. Vitek, H. Dawson, and S. Bullman. “Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.Neuroscience 99, no. 4 (2000): 705–10. https://doi.org/10.1016/s0306-4522(00)00234-7.
Goldstein LB, Vitek MP, Dawson H, Bullman S. Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. Neuroscience. 2000;99(4):705–10.
Goldstein, L. B., et al. “Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse.Neuroscience, vol. 99, no. 4, 2000, pp. 705–10. Pubmed, doi:10.1016/s0306-4522(00)00234-7.
Goldstein LB, Vitek MP, Dawson H, Bullman S. Expression of the apolipoprotein E gene does not affect motor recovery after sensorimotor cortex injury in the mouse. Neuroscience. 2000;99(4):705–710.
Journal cover image

Published In

Neuroscience

DOI

ISSN

0306-4522

Publication Date

2000

Volume

99

Issue

4

Start / End Page

705 / 710

Location

United States

Related Subject Headings

  • Somatosensory Cortex
  • Recovery of Function
  • Postural Balance
  • Neurology & Neurosurgery
  • Motor Cortex
  • Mice, Knockout
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Locomotion