Triplet repeats form secondary structures that escape DNA repair in yeast.
Publication
, Journal Article
Moore, H; Greenwell, PW; Liu, CP; Arnheim, N; Petes, TD
Published in: Proc Natl Acad Sci U S A
February 16, 1999
Several human neurodegenerative diseases result from expansion of CTG/CAG or CGG/CCG triplet repeats. The finding that single-stranded CNG repeats form hairpin-like structures in vitro has led to the hypothesis that DNA secondary structure formation is an important component of the expansion mechanism. We show that single-stranded DNA loops containing 10 CTG/CAG or CGG/CCG repeats are inefficiently repaired during meiotic recombination in Saccharomyces cerevisiae. Comparisons of the repair of DNA loops with palindromic and nonpalindromic sequences suggest that this inefficient repair reflects the ability of these sequences to form hairpin structures in vivo.
Duke Scholars
Altmetric Attention Stats
Dimensions Citation Stats
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
February 16, 1999
Volume
96
Issue
4
Start / End Page
1504 / 1509
Location
United States
Related Subject Headings
- Trinucleotide Repeats
- Saccharomyces cerevisiae
- Recombination, Genetic
- Plasmids
- Nucleic Acid Conformation
- Neurodegenerative Diseases
- Molecular Sequence Data
- Meiosis
- Humans
- Haploidy
Citation
APA
Chicago
ICMJE
MLA
NLM
Moore, H., Greenwell, P. W., Liu, C. P., Arnheim, N., & Petes, T. D. (1999). Triplet repeats form secondary structures that escape DNA repair in yeast. Proc Natl Acad Sci U S A, 96(4), 1504–1509. https://doi.org/10.1073/pnas.96.4.1504
Moore, H., P. W. Greenwell, C. P. Liu, N. Arnheim, and T. D. Petes. “Triplet repeats form secondary structures that escape DNA repair in yeast.” Proc Natl Acad Sci U S A 96, no. 4 (February 16, 1999): 1504–9. https://doi.org/10.1073/pnas.96.4.1504.
Moore H, Greenwell PW, Liu CP, Arnheim N, Petes TD. Triplet repeats form secondary structures that escape DNA repair in yeast. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1504–9.
Moore, H., et al. “Triplet repeats form secondary structures that escape DNA repair in yeast.” Proc Natl Acad Sci U S A, vol. 96, no. 4, Feb. 1999, pp. 1504–09. Pubmed, doi:10.1073/pnas.96.4.1504.
Moore H, Greenwell PW, Liu CP, Arnheim N, Petes TD. Triplet repeats form secondary structures that escape DNA repair in yeast. Proc Natl Acad Sci U S A. 1999 Feb 16;96(4):1504–1509.
Published In
Proc Natl Acad Sci U S A
DOI
ISSN
0027-8424
Publication Date
February 16, 1999
Volume
96
Issue
4
Start / End Page
1504 / 1509
Location
United States
Related Subject Headings
- Trinucleotide Repeats
- Saccharomyces cerevisiae
- Recombination, Genetic
- Plasmids
- Nucleic Acid Conformation
- Neurodegenerative Diseases
- Molecular Sequence Data
- Meiosis
- Humans
- Haploidy