LAB: a new membrane-associated adaptor molecule in B cell activation.
Publication
, Journal Article
Janssen, E; Zhu, M; Zhang, W; Koonpaew, S; Zhang, W
Published in: Nat Immunol
February 2003
The adaptor molecule, linker for activation of T cells (LAT), is essential in T cell activation and development; a similar molecule in B cells has not yet been identified. Here, we report the identification of a new adaptor protein, linker for activation of B cells (LAB). Like LAT, LAB was localized to lipid rafts. Upon activation via the B cell receptor (BCR), LAB was phosphorylated and interacted with the adaptor protein Grb2. Decreased LAB expression led to a reduction in BCR-mediated calcium flux and Erk activation. LAB rescued thymocyte development but not normal T cell activation in LAT(-/-) mice. Our data suggest that LAB links BCR engagement to downstream signaling pathways.
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Published In
Nat Immunol
DOI
ISSN
1529-2908
Publication Date
February 2003
Volume
4
Issue
2
Start / End Page
117 / 123
Location
United States
Related Subject Headings
- Tyrosine
- Tissue Distribution
- Signal Transduction
- Sequence Homology, Amino Acid
- RNA, Messenger
- Proteins
- Phosphorylation
- Phosphoproteins
- Molecular Sequence Data
- Mice, Knockout
Citation
APA
Chicago
ICMJE
MLA
NLM
Janssen, E., Zhu, M., Zhang, W., & Koonpaew, S. (2003). LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol, 4(2), 117–123. https://doi.org/10.1038/ni882
Janssen, Erin, Minghua Zhu, Weijia Zhang, Surapong Koonpaew, and Weiguo Zhang. “LAB: a new membrane-associated adaptor molecule in B cell activation.” Nat Immunol 4, no. 2 (February 2003): 117–23. https://doi.org/10.1038/ni882.
Janssen E, Zhu M, Zhang W, Koonpaew S. LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol. 2003 Feb;4(2):117–23.
Janssen, Erin, et al. “LAB: a new membrane-associated adaptor molecule in B cell activation.” Nat Immunol, vol. 4, no. 2, Feb. 2003, pp. 117–23. Pubmed, doi:10.1038/ni882.
Janssen E, Zhu M, Zhang W, Koonpaew S. LAB: a new membrane-associated adaptor molecule in B cell activation. Nat Immunol. 2003 Feb;4(2):117–123.
Published In
Nat Immunol
DOI
ISSN
1529-2908
Publication Date
February 2003
Volume
4
Issue
2
Start / End Page
117 / 123
Location
United States
Related Subject Headings
- Tyrosine
- Tissue Distribution
- Signal Transduction
- Sequence Homology, Amino Acid
- RNA, Messenger
- Proteins
- Phosphorylation
- Phosphoproteins
- Molecular Sequence Data
- Mice, Knockout