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Heme oxygenase 1 is required for mammalian iron reutilization.

Publication ,  Journal Article
Poss, KD; Tonegawa, S
Published in: Proc Natl Acad Sci U S A
September 30, 1997
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The majority of iron for essential mammalian biological activities such as erythropoiesis is thought to be reutilized from cellular hemoproteins. Here, we generated mice lacking functional heme oxygenase 1 (Hmox1; EC 1.14.99.3), which catabolizes heme to biliverdin, carbon monoxide, and free iron, to assess its participation in iron homeostasis. Hmox1-deficient adult mice developed an anemia associated with abnormally low serum iron levels, yet accumulated hepatic and renal iron that contributed to macromolecular oxidative damage, tissue injury, and chronic inflammation. Our results indicate that Hmox1 has an important recycling role by facilitating the release of iron from hepatic and renal cells, and describe a mouse model of human iron metabolic disorders.

Duke Scholars

Kenneth Daniel Poss
Author Kenneth Daniel Poss Cell Biology
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Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.94.20.10919

ISSN

0027-8424

Publication Date

September 30, 1997

Volume

94

Issue

20

Start / End Page

10919 / 10924

Location

United States

Related Subject Headings

  • Oxidative Stress
  • Mutation
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Iron
  • Homeostasis
  • Heme Oxygenase (Decyclizing)
  • Gene Targeting
  • Female
 

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Poss, K. D., & Tonegawa, S. (1997). Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A, 94(20), 10919–10924. https://doi.org/10.1073/pnas.94.20.10919
Poss, K. D., and S. Tonegawa. “Heme oxygenase 1 is required for mammalian iron reutilization.” Proc Natl Acad Sci U S A 94, no. 20 (September 30, 1997): 10919–24. https://doi.org/10.1073/pnas.94.20.10919.
Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10919–24.
Poss, K. D., and S. Tonegawa. “Heme oxygenase 1 is required for mammalian iron reutilization.” Proc Natl Acad Sci U S A, vol. 94, no. 20, Sept. 1997, pp. 10919–24. Pubmed, doi:10.1073/pnas.94.20.10919.
Poss KD, Tonegawa S. Heme oxygenase 1 is required for mammalian iron reutilization. Proc Natl Acad Sci U S A. 1997 Sep 30;94(20):10919–10924.
Journal cover image

Published In

Proc Natl Acad Sci U S A

DOI

10.1073/pnas.94.20.10919

ISSN

0027-8424

Publication Date

September 30, 1997

Volume

94

Issue

20

Start / End Page

10919 / 10924

Location

United States

Related Subject Headings

  • Oxidative Stress
  • Mutation
  • Mice, Inbred C57BL
  • Mice
  • Male
  • Iron
  • Homeostasis
  • Heme Oxygenase (Decyclizing)
  • Gene Targeting
  • Female