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Haem oxygenase-1 prevents cell death by regulating cellular iron.

Publication ,  Journal Article
Ferris, CD; Jaffrey, SR; Sawa, A; Takahashi, M; Brady, SD; Barrow, RK; Tysoe, SA; Wolosker, H; Barañano, DE; Doré, S; Poss, KD; Snyder, SH
Published in: Nat Cell Biol
July 1999

Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death: iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.

Duke Scholars

Published In

Nat Cell Biol

DOI

ISSN

1465-7392

Publication Date

July 1999

Volume

1

Issue

3

Start / End Page

152 / 157

Location

England

Related Subject Headings

  • Transfection
  • Staurosporine
  • Skin
  • Recombinant Proteins
  • Mice, Knockout
  • Mice
  • Membrane Proteins
  • Iron
  • Humans
  • Heme Oxygenase-1
 

Citation

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Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., … Snyder, S. H. (1999). Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol, 1(3), 152–157. https://doi.org/10.1038/11072
Ferris, C. D., S. R. Jaffrey, A. Sawa, M. Takahashi, S. D. Brady, R. K. Barrow, S. A. Tysoe, et al. “Haem oxygenase-1 prevents cell death by regulating cellular iron.Nat Cell Biol 1, no. 3 (July 1999): 152–57. https://doi.org/10.1038/11072.
Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, et al. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol. 1999 Jul;1(3):152–7.
Ferris, C. D., et al. “Haem oxygenase-1 prevents cell death by regulating cellular iron.Nat Cell Biol, vol. 1, no. 3, July 1999, pp. 152–57. Pubmed, doi:10.1038/11072.
Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Barañano DE, Doré S, Poss KD, Snyder SH. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol. 1999 Jul;1(3):152–157.

Published In

Nat Cell Biol

DOI

ISSN

1465-7392

Publication Date

July 1999

Volume

1

Issue

3

Start / End Page

152 / 157

Location

England

Related Subject Headings

  • Transfection
  • Staurosporine
  • Skin
  • Recombinant Proteins
  • Mice, Knockout
  • Mice
  • Membrane Proteins
  • Iron
  • Humans
  • Heme Oxygenase-1