Haem oxygenase-1 prevents cell death by regulating cellular iron.
Publication
, Journal Article
Ferris, CD; Jaffrey, SR; Sawa, A; Takahashi, M; Brady, SD; Barrow, RK; Tysoe, SA; Wolosker, H; Barañano, DE; Doré, S; Poss, KD; Snyder, SH
Published in: Nat Cell Biol
July 1999
Haem oxygenase-1 (HO1) is a heat-shock protein that is induced by stressful stimuli. Here we demonstrate a cytoprotective role for HO1: cell death produced by serum deprivation, staurosporine or etoposide is markedly accentuated in cells from mice with a targeted deletion of the HO1 gene, and greatly reduced in cells that overexpress HO1. Iron efflux from cells is augmented by HO1 transfection and reduced in HO1-deficient fibroblasts. Iron accumulation in HO1-deficient cells explains their death: iron chelators protect HO1-deficient fibroblasts from cell death. Thus, cytoprotection by HO1 is attributable to its augmentation of iron efflux, reflecting a role for HO1 in modulating intracellular iron levels and regulating cell viability.
Duke Scholars
Published In
Nat Cell Biol
DOI
ISSN
1465-7392
Publication Date
July 1999
Volume
1
Issue
3
Start / End Page
152 / 157
Location
England
Related Subject Headings
- Transfection
- Staurosporine
- Skin
- Recombinant Proteins
- Mice, Knockout
- Mice
- Membrane Proteins
- Iron
- Humans
- Heme Oxygenase-1
Citation
APA
Chicago
ICMJE
MLA
NLM
Ferris, C. D., Jaffrey, S. R., Sawa, A., Takahashi, M., Brady, S. D., Barrow, R. K., … Snyder, S. H. (1999). Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol, 1(3), 152–157. https://doi.org/10.1038/11072
Ferris, C. D., S. R. Jaffrey, A. Sawa, M. Takahashi, S. D. Brady, R. K. Barrow, S. A. Tysoe, et al. “Haem oxygenase-1 prevents cell death by regulating cellular iron.” Nat Cell Biol 1, no. 3 (July 1999): 152–57. https://doi.org/10.1038/11072.
Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, et al. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol. 1999 Jul;1(3):152–7.
Ferris, C. D., et al. “Haem oxygenase-1 prevents cell death by regulating cellular iron.” Nat Cell Biol, vol. 1, no. 3, July 1999, pp. 152–57. Pubmed, doi:10.1038/11072.
Ferris CD, Jaffrey SR, Sawa A, Takahashi M, Brady SD, Barrow RK, Tysoe SA, Wolosker H, Barañano DE, Doré S, Poss KD, Snyder SH. Haem oxygenase-1 prevents cell death by regulating cellular iron. Nat Cell Biol. 1999 Jul;1(3):152–157.
Published In
Nat Cell Biol
DOI
ISSN
1465-7392
Publication Date
July 1999
Volume
1
Issue
3
Start / End Page
152 / 157
Location
England
Related Subject Headings
- Transfection
- Staurosporine
- Skin
- Recombinant Proteins
- Mice, Knockout
- Mice
- Membrane Proteins
- Iron
- Humans
- Heme Oxygenase-1