Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.
Publication
, Journal Article
Poss, KD; Nechiporuk, A; Stringer, KF; Lee, C; Keating, MT
Published in: Genes Dev
July 1, 2004
Aneuploidy, resulting from chromosome missegregation during meiosis, is a major cause of human infertility and birth defects. However, its molecular basis remains incompletely understood. Here we have identified a spectrum of chromosome anomalies in embryos of zebrafish homozygous for a hypomorphic mutation in Mps1, a kinase required for the mitotic checkpoint. These aneuploidies are caused by meiotic error and result in severe developmental defects. Our results reveal Mps1 as a critical regulator of chromosome number in zebrafish, and demonstrate how slight genetic perturbation of a mitotic checkpoint factor can dramatically reduce the fidelity of chromosome segregation during vertebrate meiosis.
Duke Scholars
Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
July 1, 2004
Volume
18
Issue
13
Start / End Page
1527 / 1532
Location
United States
Related Subject Headings
- Zebrafish Proteins
- Zebrafish
- Testis
- Spermatozoa
- Protein-Tyrosine Kinases
- Protein Serine-Threonine Kinases
- Protein Kinases
- Oocytes
- Mutation
- Mitosis
Citation
APA
Chicago
ICMJE
MLA
NLM
Poss, K. D., Nechiporuk, A., Stringer, K. F., Lee, C., & Keating, M. T. (2004). Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes Dev, 18(13), 1527–1532. https://doi.org/10.1101/gad.1182604
Poss, Kenneth D., Alex Nechiporuk, Keith F. Stringer, Charles Lee, and Mark T. Keating. “Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.” Genes Dev 18, no. 13 (July 1, 2004): 1527–32. https://doi.org/10.1101/gad.1182604.
Poss KD, Nechiporuk A, Stringer KF, Lee C, Keating MT. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes Dev. 2004 Jul 1;18(13):1527–32.
Poss, Kenneth D., et al. “Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1.” Genes Dev, vol. 18, no. 13, July 2004, pp. 1527–32. Pubmed, doi:10.1101/gad.1182604.
Poss KD, Nechiporuk A, Stringer KF, Lee C, Keating MT. Germ cell aneuploidy in zebrafish with mutations in the mitotic checkpoint gene mps1. Genes Dev. 2004 Jul 1;18(13):1527–1532.
Published In
Genes Dev
DOI
ISSN
0890-9369
Publication Date
July 1, 2004
Volume
18
Issue
13
Start / End Page
1527 / 1532
Location
United States
Related Subject Headings
- Zebrafish Proteins
- Zebrafish
- Testis
- Spermatozoa
- Protein-Tyrosine Kinases
- Protein Serine-Threonine Kinases
- Protein Kinases
- Oocytes
- Mutation
- Mitosis