Skip to main content
Journal cover image

Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells.

Publication ,  Journal Article
Buckley, PJ; Dickson, SA
Published in: Am J Clin Pathol
August 1984

Most of the monoclonal antibodies (MoAbs) to T-lymphocyte subsets are, with few exceptions thought to recognize antigens (Ags) unique to T-cells. The authors examined the distribution of cells reacting with MoAbs to the helper/inducer (OKT4, anti-Leu-3a,b) and suppressor/cytotoxic (OKT8, anti-Leu-2a) T-lymphocyte subsets and to "pan T" Ags (anti-Leu-1, anti-Leu-4) in sections from frozen human spleen. In addition to recognizing lymphocytes in the T-zone (periarteriolar lymphoid sheaths), MoAbs to the helper/inducer and suppressor/cytotoxic T-cell subsets reacted distinctly with the red pulp sinusoidal lining cells. MoAbs to "pan T" Ags also reacted with T-zone lymphocytes but did not react with sinusoidal lining cells. MoAbs to the helper/inducer and suppressor/cytotoxic subsets of T-lymphocytes do not appear to identify Ags unique to these cells.

Duke Scholars

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

August 1984

Volume

82

Issue

2

Start / End Page

167 / 172

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes
  • Spleen
  • Pathology
  • Humans
  • Antigens, Surface
  • Antigen-Antibody Reactions
  • Antibodies, Monoclonal
 

Citation

APA
Chicago
ICMJE
MLA
NLM
Buckley, P. J., & Dickson, S. A. (1984). Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells. Am J Clin Pathol, 82(2), 167–172. https://doi.org/10.1093/ajcp/82.2.167
Buckley, P. J., and S. A. Dickson. “Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells.Am J Clin Pathol 82, no. 2 (August 1984): 167–72. https://doi.org/10.1093/ajcp/82.2.167.
Buckley, P. J., and S. A. Dickson. “Monoclonal antibodies to T-helper/inducer and T-suppressor/cytotoxic lymphocyte subsets recognize antigens on splenic sinusoidal lining cells.Am J Clin Pathol, vol. 82, no. 2, Aug. 1984, pp. 167–72. Pubmed, doi:10.1093/ajcp/82.2.167.
Journal cover image

Published In

Am J Clin Pathol

DOI

ISSN

0002-9173

Publication Date

August 1984

Volume

82

Issue

2

Start / End Page

167 / 172

Location

England

Related Subject Headings

  • T-Lymphocytes, Regulatory
  • T-Lymphocytes, Helper-Inducer
  • T-Lymphocytes, Cytotoxic
  • T-Lymphocytes
  • Spleen
  • Pathology
  • Humans
  • Antigens, Surface
  • Antigen-Antibody Reactions
  • Antibodies, Monoclonal