The myoD gene family: nodal point during specification of the muscle cell lineage.
Publication
, Journal Article
Weintraub, H; Davis, R; Tapscott, S; Thayer, M; Krause, M; Benezra, R; Blackwell, TK; Turner, D; Rupp, R; Hollenberg, S
Published in: Science
February 15, 1991
The myoD gene converts many differentiated cell types into muscle. MyoD is a member of the basic-helix-loop-helix family of proteins; this 68-amino acid domain in MyoD is necessary and sufficient for myogenesis. MyoD binds cooperatively to muscle-specific enhancers and activates transcription. The helix-loop-helix motif is responsible for dimerization, and, depending on its dimerization partner, MyoD activity can be controlled. MyoD senses and integrates many facets of cell state. MyoD is expressed only in skeletal muscle and its precursors; in nonmuscle cells myoD is repressed by specific genes. MyoD activates its own transcription; this may stabilize commitment to myogenesis.
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Published In
Science
DOI
ISSN
0036-8075
Publication Date
February 15, 1991
Volume
251
Issue
4995
Start / End Page
761 / 766
Location
United States
Related Subject Headings
- MyoD Protein
- Muscles
- Muscle Proteins
- Multigene Family
- Humans
- Genes, Regulator
- General Science & Technology
- Gene Expression Regulation
- DNA-Binding Proteins
- Cell Differentiation
Citation
APA
Chicago
ICMJE
MLA
NLM
Weintraub, H., Davis, R., Tapscott, S., Thayer, M., Krause, M., Benezra, R., … Hollenberg, S. (1991). The myoD gene family: nodal point during specification of the muscle cell lineage. Science, 251(4995), 761–766. https://doi.org/10.1126/science.1846704
Weintraub, H., R. Davis, S. Tapscott, M. Thayer, M. Krause, R. Benezra, T. K. Blackwell, D. Turner, R. Rupp, and S. Hollenberg. “The myoD gene family: nodal point during specification of the muscle cell lineage.” Science 251, no. 4995 (February 15, 1991): 761–66. https://doi.org/10.1126/science.1846704.
Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, et al. The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991 Feb 15;251(4995):761–6.
Weintraub, H., et al. “The myoD gene family: nodal point during specification of the muscle cell lineage.” Science, vol. 251, no. 4995, Feb. 1991, pp. 761–66. Pubmed, doi:10.1126/science.1846704.
Weintraub H, Davis R, Tapscott S, Thayer M, Krause M, Benezra R, Blackwell TK, Turner D, Rupp R, Hollenberg S. The myoD gene family: nodal point during specification of the muscle cell lineage. Science. 1991 Feb 15;251(4995):761–766.
Published In
Science
DOI
ISSN
0036-8075
Publication Date
February 15, 1991
Volume
251
Issue
4995
Start / End Page
761 / 766
Location
United States
Related Subject Headings
- MyoD Protein
- Muscles
- Muscle Proteins
- Multigene Family
- Humans
- Genes, Regulator
- General Science & Technology
- Gene Expression Regulation
- DNA-Binding Proteins
- Cell Differentiation