Loss of heterozygosity for 10q loci in human gliomas.
Publication
, Journal Article
Rasheed, BK; Fuller, GN; Friedman, AH; Bigner, DD; Bigner, SH
Published in: Genes Chromosomes Cancer
July 1992
Cytogenetic and RFLP studies have shown that chromosome 10 is frequently lost in tumor cells from glioblastomas, suggesting that a suppressor gene important in tumorigenesis is present on this chromosome. Forty-one tumors were examined for loss of heterozygosity at 23 loci on chromosome 10 to determine the smallest common deletion interval on this chromosome. Seven tumors did not lose heterozygosity for any of the markers. Twenty-three tumors lost an allele for all the informative loci. In 11 tumors heterozygosity was maintained at some loci and lost at other loci, indicating partial deletion of chromosome 10. The common region of deletion in these 11 tumors was located in 10q24-q26 between the markers pHUK-8 and pMCT122.2.
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Published In
Genes Chromosomes Cancer
DOI
ISSN
1045-2257
Publication Date
July 1992
Volume
5
Issue
1
Start / End Page
75 / 82
Location
United States
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Oncology & Carcinogenesis
- Male
- Humans
- Glioma
- Glioblastoma
- Genetic Markers
- Female
- DNA Probes
- Chromosomes, Human, Pair 10
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Rasheed, B. K., Fuller, G. N., Friedman, A. H., Bigner, D. D., & Bigner, S. H. (1992). Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosomes Cancer, 5(1), 75–82. https://doi.org/10.1002/gcc.2870050111
Rasheed, B. K., G. N. Fuller, A. H. Friedman, D. D. Bigner, and S. H. Bigner. “Loss of heterozygosity for 10q loci in human gliomas.” Genes Chromosomes Cancer 5, no. 1 (July 1992): 75–82. https://doi.org/10.1002/gcc.2870050111.
Rasheed BK, Fuller GN, Friedman AH, Bigner DD, Bigner SH. Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosomes Cancer. 1992 Jul;5(1):75–82.
Rasheed, B. K., et al. “Loss of heterozygosity for 10q loci in human gliomas.” Genes Chromosomes Cancer, vol. 5, no. 1, July 1992, pp. 75–82. Pubmed, doi:10.1002/gcc.2870050111.
Rasheed BK, Fuller GN, Friedman AH, Bigner DD, Bigner SH. Loss of heterozygosity for 10q loci in human gliomas. Genes Chromosomes Cancer. 1992 Jul;5(1):75–82.
Published In
Genes Chromosomes Cancer
DOI
ISSN
1045-2257
Publication Date
July 1992
Volume
5
Issue
1
Start / End Page
75 / 82
Location
United States
Related Subject Headings
- Polymorphism, Restriction Fragment Length
- Oncology & Carcinogenesis
- Male
- Humans
- Glioma
- Glioblastoma
- Genetic Markers
- Female
- DNA Probes
- Chromosomes, Human, Pair 10